Graduate School of Pharmaceutical Sciences, Kyushu University

Bioorganic and Synthetic Chemistry

Publication (2019-1997)

  1. Taniguchi Y., Sagara I., Nagata Y., Kikukawa Y., Sasaki S.
    Effect of the 2-substituted adenosine-1,3-diazaphenoxazine 5'-triphosphate derivatives on thesingle primer extension reaction byDNA polymerase,Chem. Pharm. Bull.(2019)
  2. Kikuta K., Taniguchi Y., Sasaki S.*
    Study of the inducible cross-linking reaction to mRNA and the effect on the translation,Chem. Pharm. Bull.(2019)
  3. Sasaki S.*
    Development of Novel Functional Molecules Targeting DNA and RNA,Chem. Pharm. Bull.67(6), 508-518 (2019) DOI:
  4. Thavoncharoensub N., Maruyama K., Heh C.H., Leong K.H., Shi H., Shigematsu Y., Sasaki S. and Taniguchi Y.*
    Synthesis of g-N-modified 8-oxo-2'-deoxyguanosinetriphosphate and its characterization,Nucleosides, Nucleotides andNucleic Acids.38(8), 578-589 (2019) 
  5. Taniguchi Y.*, Wang L., Okamura H. and Sasaki S.*
    Synthesis of 2'-deoxy-4-aminopyridinylpseudocytidine derivatives for incorporation into triplex forming oligonucleotides,CurrentProtocoles in Nucleic Acids Chemistry.  77(1), e80 (2019)DOI:

                     Chem. Pharm. Bull  

  6. Wang L., Taniguchi Y.*, Okamura H. and Sasaki S.*
    Modification of the aminopyridine unit of 2'-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at CG interruptions inhomopurine sequences,Nucleic Acids Res. 46(17) 8679-8688 (2018)DOI: 
  7. Fuchi Y, Fukuda T and  Sasaki S,*
    Luminescent Europium Sensors for Specific Detection of 8-oxo-dGTP by Time-gated Fluorescence ,Bioorg. Med. Chem.,26(12) 3254-3260 (2018)  DOI: 
  8. Murase H. Noguchi T. and Sasaki S.*
    Evaluation of simultaneous binding of Chromomycin A3 to the multiple sites of DNA by the new restriction enzyme assay,Bioorg. Med. Chem. Lett.,28(10) 1832-1835(2018).  DOI: 
  9. Taniguchi Y.*, Miyazaki M., Matsueda N., Wang L., Okamura H. and Sasaki S.*
    Stable and Selective Antiparallel Type Triplex DNA Formation by Targeting a GC base pair with the TFO containing One N2-Phenyl-2'-deoxyguanosine,Chem. Pharm. Bull.66(6), 624-631 (2018)  DOI:
    Highlighted paper selected by Editor-in-Chief

                  Nucleic Acids Res
              Bioorg. Med. Chem. Lett.                                    Chem. Pharm. Bull                       Bioorg. Med. Chem

  10. Wang L., Taniguchi Y.*, Okamura H. and Sasaki S.*
    Effect of the 3-halosubstitution of the 2'-deoxy aminopyridinyl-pseudocytidine derivatives on the selectivity and stability ofantiparallel triplex DNA with a CG inversion site,Bioorg. Med.Chem.,25(14), 3853-3860 (2017)  DOI: https://10.1016/j.bmc.2017.05.035
  11. Taniguchi Y.*
    Development of damaged nucleoside mimics for inhibition of their repair enzymes,YAKUGAKU ZASSHI137(3), 293-300 (2017)  DOI:
  12. Kawara K., Tsuji G., Taniguchi Y., Sasaki S.*
    Synchronized Chiral Induction Between [5] Helicene-Spermine Ligand and B-Z DNA transition,Chemistry - A EuropeanJournal.23(8), 1763-1769 (2017)  Doi: 10.1002/chem.201605276.

         Chem. Eur. J.                                  Bioorg. Med. Chem.                                       YAKUGAKU ZASSHI

  13. Okamura H,, Taniguchi Y.*, Sasaki S.*,
    Aminopyridinyl-pseudodeoxycytidine derivatives selectively stabilize antiparallel triplex DNA with multiple CG inversion sites.Angew. Chem. Int. Ed.55(40), 12445-12449 (2016)  DOI: 10.1002/anie201606136
  14. Fuchi Y., Fukuda T., Sasaki S.*,
    Synthetic Receptor Molecules for Selective Fluorescent Detection of 8-oxo-dGTP in Aqueous Media,Org. Biomol. Chem.14,7949-7955 (2016)  doi: 10.1039/C6OB01485B
  15. Yin Y., Sasaki S., Taniguchi Y.*,
    Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerase and cell proliferation,Bioorg.Med. Chem. 24(16), 3856-3861 (2016)  doi: 10.1016/j.bmc.2016.06.030
  16. Nishioka T., Oshiro I., Onizuka K., Taniguchi Y. and Sasaki S.*,
    Efficient thymidine-selective DNA interstrand photo-activecrosslinking by the 6-thioguanine connected via an ethylene-linker tothe 2'-deoxyribose unit,Chem. Pharm. Bull.64(9),1315-1320 (2016)
  17. Koga Y., Taniguchi Y*, Kikukawa Y, Sasaki S*,
    Recognition and detection of 8-oxo-rG in RNA using the DNA/OMeRNA chimera probes containing fluorescent adenosine-diazaphenoxazine analogue,Bioorg. Med. Chem. 24(6), 1308-1313(2016)  doi: 10.1016/j.bmc.2016.02.001
  18. Abe S. Y., Sasaki S*,
    DNA cleavage at the AP site viab-elimination mediated by the AP sitebindingligands,Bioorg. Med.Chem. 24(4) 910-914(2016);  doi: 10.1016/j.bmc.2016.01.016
  19. Yin Y., Sasaki S., Taniguchi Y.*,
    Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosineTriphosphatase, hMTH1, Actibities,ChemBioChem, 17(7) 566-569 (2016)  doi/10.1002/cbic.201500589.

            Org. Biomol. Chem                                Angew Chem Int. Ed.
             Bioorg. Med. Chem.                                                               Chem. Pharm. Bull.
                     ChemBioChem                         Bioorg. Med. Chem.    Bioorg. Med. Chem.

  20. Fuchi Y, Sasaki S*,
    New NitroG-Grasp Molecules with Enhanced Capture Reactivity for 8-Nitroguanosine in the AqueousMedia,Chem. Pharm. Bull.63 (11) 913-919. (2015)
  21. Taniguchi Y*, Tomizaki A, Matsueda N, Okamura H, Sasaki S*,
    Enhancement of TFO Triplex Formation by Conjugation with Pyrene via Click Chemistry,Chem. Pharm. Bull.63 (11) 920-926.(2015)
  22. Koda H., Brazier J., Onishi I., Sasaki S*,
    Strong Positive Cooperativity in Binding to the A3T3 Repeat by Hoechst 33258 Derivatives Attaching the Quinoline Units at theend of a Branched Linker,Bioorg. Med. Chem.23(15), 4583-4590 (2015)  doi:10.1016/j.bmc.2015.05.056
  23. Kikuta K. Haishun P. Brazier J. Taniguchi Y. Onizuka K. Nagatsugi F. Sasaki S*.
    Stabilization of the i-motif structure by theintrastrand cross-link formation,Bioorg. Med. Chem. Lett.25(16), 3307-3310 (2015)  doi:10.1016/j.bmcl.2015.05.064
  24. Oshiro I. Jitsuzaki D. Onizuka K. Nishimoto A. Taniguchi Y. and Sasaki S*.
    Site-specific modification of the 6-amino group of adenosine in RNA by an inter-strand functionality-transfer reaction using an S-functionalized-4-thiothymidine,ChemBioChem, 16(8), 1199-1204 (2015)  doi: 10.1002/cbic.201500084
  25. Yin Y. Sasaki S. and Taniguchi Y*.
    Recognition and excision properties of 8-halogenated-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguaanosine analogues andFPG and hOGG1 inhibitors,ChemBioChem, 16(8), 1190-1198 (2015)  doi: 10.1002/cbic.201402690
  26. Taniguchi Y*., Kikukawa Y and Sasaki S*.
    Discrimination Between 8-Oxo-2'-Deoxyguanosine and 2'-Deoxyguanosine in  DNA by the Single Nucleotide PrimerExtension Reaction with Adap Triphosphate,Angew. Chem. Int. Ed.54(17), 5147-5151(2015)  doi: 10.102/anie.201412086.
  27. Fuchi Y., Obayashi H. and Sasaki S*.
    Development of New 1,3-Diazaphenoxazine Derivatives (ThioG-Grasp) to Covalently Capture 8-Thioguanosine,Molecules.,20(1),1078-1087 (2015)  doi: 10.3390/molecules20011078.

            Chem. Pharm. Bull.
                     Bioorg. Med. Chem. Lett.                  Chem. Pharm. Bull.
                   ChemBioChem                              ChemBioChem                           Bioorg. Med. Chem.
                              Molecules                                                        Angew Chem Int. Ed.

  28. Okamura H., Taniguchi Y*. and Sasaki S*.
    An Isocytidine Derivative with a 2-Amino-6-methylpyridine Unit for Selective Recognition of the CG Interrupting Site in anAntiparallel Triplex DNA,ChemBioChem.15(16), 2374-2378 (2014)  doi: 10.1002/cbic.201402328,.
  29. Jitsuzaki D., Onizuka K., Nishimoto A., Oshiro I., Taniguchi Y. and Sasaki S*.
    Remarkable acceleration of the DNA/RNA inter-strand functionality-transfer reaction to modify a cytosine residue: the proximityeffect via complexation with a metalcation,Nucleic Acids Res.,42(13), 8808-8815 (2014)  doi: 10.1093/nar/gku538.
  30. Yamada Y. Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S. and Harashima H.
    Ananocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line,Biomaterials, 35(24), 6430-6438(2014)  DOI: 10.1016/j.biomaterials.2014.04.017
  31. Fuchi Y. and Sasaki S.*,
    Efficient Covalent Capture of 8-Nitroguanosine via a Multiple Hydrogen-Bonded.Org. Lett., 16(6),1760-1763 (2014)  doi:10.1021/ol500452r
  32. Goto T., Shiina A., Murata T., Tomii M., YamazakiT., Yoshida K., Yoshino T., Suzuki O., Sogawa Y., Mizukami K., TakagiN.,Yoshitomi T., Etori M., Tsuchida H., Mikkaichi T., Nakao N., Takahashi M., Takahashi H, Sasaki S.
    Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highlyselective PDE4B inhibitors,Bioorg.Med. Chem.Lett., 24(3), 893-899 (2014)  DOi: 10.1016/j.bmcl.2013.12.076
  33. Yizhen Y., Taniguchi Y.* and Sasaki S.*,
    Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its basepairing properties.Tetrahedron, 70(11), 2040-2047 (2014)  doi: 10.1016/j.tet.2014.01.047.
  34. Taniguchi Y.*, Fukabori K., Kikukawa Y., Koga Y and Sasaki S.*,
    2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dG inDNA.  Bioorg. Med. Chem. 22(5), 1634-1641 (2014)  DOI:
  35. Taniguchi Y., Koga Y., Shigeki Sasaki*. Synthesis of 8-oxoguanosine phosphoramidite and its incorporation intooligoribonucleotides.Current Protocols in Nucleic Acid Chemistry, UNIT4.58 56:4.58.1-4.58.10  DOI:10.1002/0471142700.nc0458s56

                              Org. Lett.                                                                Nucleic Acids Res.
                     Bioorg. Med. Chem.                                                               Tetrahedron

  36. Sasaki H. and Sasaki S*.
    B-Z Transition of (dA-T)n Duplex Induced by Spermine Porphyrin-Conjugate via anIntermediateDNA Conformation.Chem. Comm.,49(79) 9024-9026(2013)  DOI: 10.1039/C3CC45213A
  37. Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N.,Takahashi M., Hasegawa M. and Sasaki S.
    Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidinederivativesas novel and potent PDE4 inhibitors.Bioorg.Med. Chem. 21 (22) 7025-7037 (2013).  DOI:
  38. Tsuji G,, Kawakami K and Sasaki S*.
    Enantioselective Binding of Chiral 1,14-Dimethyl[5]Helicene-spermine Ligands with B-and Z-DNA.Bioorg. Med. Chem. 21 (19)6063-6068 (2013).  DOI:
  39. Okamura H, Taniguchi Y* and Sasaki S*.
    N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits a selective recognition ofa CG interrupting site for the formation of anti-parallel triplexes,Org. Biomol. Chem., 11. 3918-3924 (2013)  DOI: 10.1039/C3OB40472B
  40. Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N.,TakahashiM., Hasegawa M. and Sasaki S.
    Identification of the fused bicyclic4-amino-2-phenylpyrimidine derivatives as noveland potent PDE4 inhibitors.Bioorg. Med.Chem. Lett., 23(11), 3325-3328 (2013)  DOI:
  41. Nishimoto A., Jitsuzaki D., Onizuka K., Taniguchi Y., Nagatsugi F. and Sasaki S*.
    4-Vinyl-Substituted PyrimidineNucleosides Exhibit the Efficient and SelectiveFormation of Interstrand Cross-Links with RNA andduplex DNA,NucleicAcids Res.,41(13) 6774-6781 (2013)  DOI: 10.1093/nar/gkt197
  42. Koga Y., Taniguchi Y and Sasaki S*.
    Synthesis of the Oligoribonucleotides Incorporating 8-Oxo-guanosine and Evaluation oftheir Base Pairing Properties,  Nucleosides, Nucleotides and Nucleic Acids, 32(3), 124-136. (2013)  DOI: 10.1080/15257770.2013.767461
  43. Taniguchi Y., Okamura H., Fujino N., Sasaki S*.
    Synthesis of 1'-phenyl-2-OMe ribose analogues connecting the thyminebase at the 1' position through a flexible linker for theformation of a stable anti-parallele triplex DNA,Tetrahedron, 69(2), 600-606 (2013)  DOI: 10.1016/j.tet.2012.11.016 

                              Chem. Comm.
                              Org. Biomol. Chem                                                        Bioorg. Med. Chem.
                              Nucleic Acids Res.                                             Nucleosides, Nucleotides and Nucleic Acids


  44. Nasr T, Taniguchi Y., Takaki T., Okamura H., Sasaki S*.
    Properties of Oligonucleotidewith Phenyl-Substituted CarbocyclicNucleoside Analogues for the Formation ofDuplex and TriplexDNA,Nucleosides, Nucleotides and Nucleic Acids,31(12),8441-860. (2012)DOI: 10.1080/15257770.2012.737970.
  45. Taniguchi Y* and Sasaki S*.,
    An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin genewith triplex forming oligonucleotidescontaining a W-shaped nucleoside analogue (WNA-bT),Org. Biomol. Chem., 10(41),8336-8341. (2012)DOI: 10.1039/c2ob26431e
  46. Aoki E., Taniguchi Y., Wada Y., Sasaki S*,
    Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-bT) containing an ortho-methyl-substituted phenylring,ChemBioChem,. 13(8), 1152-1160 (2012)DOI: 10.1002/cbic.201200066
  47. Abe Y., Nakagawa O., Yamaguchi R., Sasaki S.*,
    Synthesis and binding properties of new selective ligands for thenucleobase opposite the AP site,Bioorg. Med. Chem. 20(11),3470-3479 (2012).DOI: 10.1016/j.bmc.2012.04.009.
  48. Onizuka K., Nishioka T., Li Z., Jitsuzaki D., Taniguchi Y. and Sasaki S.*,
    Aneficient and simple method for site-selectivemodification of O6-methyl-2'-deoxyguanosine in DNA,,Chem. Comm.,48 (33),3969-3971.DOI: 10.1039/c2cc17621a
  49. Sasaki S.*, Onizuka K., Taniguchi Y.,
    Oligonucleotide containing S-Functionalized 2'-deoxy-6-thioguanosine: Facile Toolsfor Base-Selective and Site Specific InternalModification of RNA,Current Protocols in Nucleic Acid Chemistry, 4.49.1-4.49.16 (2012)DOI: 10.1002/0471142700.nc0449s.48
  50. Taniguchi Y, Koga Y, Fukabori K, Kawaguchi R, Sasaki S.*,
    OFF-to-ON type fluorescent probe for the detection of 8-oxo-dGin DNA by the Adap-masked ODN probe,Bioorg. Med. Chem.Lett., 22(1), 543-546 (2012)DOI: 10.1016/j.bmcl.2011.10.093.

                      Org. Biomol. Chem                                  Nucleosides, Nucleotides and Nucleic Acids
                     Chem. Comm.                 ChemBioChem                          Bioorg. Med. Chem.

                              Bioorg. Med. Chem. Lett.

  51. Sasaki S., Onizuka K. and Taniguchi Y,
    The oligodeoxynucleotide probes for the site-specific modification of RNA,Chem.Soc. Rev.,40(12), 5698-5706 (2011)DOI: 10.1039/c1cs15066a.
  52. Taniguchi Y, Kawaguchi R, Sasaki S.,
    Adenosine-1,3-diazaphenoxazine Derivative for Selective Base Pair Formation with 8-Oxo-2'-deoxyguanosine in DNA,J. Am.Chem. Soc., 133, 7272-7275 (2011).DOI: 10.1021/ja200327u.
  53. Koga Y, Fuchi Y, Nakagawa O, Sasaki S.,
    Optimization of Fluorescence Property of the 8-OxodGclamp Derivative for BetterSelectivity for 8-Oxo-2'-deoxyguanosine,Tetrahedron, 67, 6746-6752 (2011).DOI: 10.1016/j/.tet.2011.03.111,
  54. Onizuka K, Shibata A, Taniguchi Y, Sasaki S.,
    Pin-Point Chemical Modification of RNA with DiverseMolecules through theFunctionality Transfer Reaction and Copper-CatalyzedAzide-Alkyne Cycloaddition Reaction,Chem. Comm.,47(17), 5004-5006 (2011).DOI: 10.10389/C1CC10582E,

                     Chem. Soc. Rev.
                     J. Am. Chem. Soc                             Tetrahedron                      Chem. Comm.

  55. Taniguchi Y., Nitta A., Park S. M., Kohara A., Uzu T., Sasaki S., The ODN probes conjugating the Cu(II) complex enhancetheluminol chemiluminescense by assembling on the DNA template,Bioorg. Med. Chem.18, 8614-8617 (2010).
  56. Doi I., Tsuji G., Kawakami K., Nakagawa O., Taniguchi Y., Sasaki S., The Spermine-Bisaryl Conjugate as a Potent Inducerforthe B to Z-DNA Transition,Chem. Eur. J.16, 11993-11999 (2010).
  57. Imoto S., Hori T., Hagihara, S., Taniguchi Y., Sasaki S., Nagatsugi F., Alteration of Cross-linking Selectivity with the 2'-OMeAnalogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense EffectBioorg. Med. Chem. Lett., 20, 6121-6124 (2010).
  58. Onizuka K., Taniguchi Y., Sasaki S., Activation and Alteration of Base Selectivity by Metal Cations in the Functionality-TransferReaction for RNA Modification,Bioconjugate Chem.21, 1508-1512 (2010).
  59. Nagatsugi F., Sasaki S., Synthesis of Reactive Oligonucleotides foe Gene Targeting and Their Application to GeneExpressionRegulation,Bull. Chem. Soc. Jpn., 83, 744-755 (2010)
  60. Li Z, Nakagawa O, Koga Y, Taniguchi Y., Sasaki S., Synthesis of New Derivatives of 8-oxoG-Clamp for Better UnderstandingtheRecognition Mode and Improvement of Selective AffinityBioorg. Med. Chem.18, 3992-3998 (2010).
  61. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S.,  The Alkyl-Connected 2-Amino-6-Vinylpurine (AVP)Crosslinking Agent for Improved Selectivity to the Cytosine,Bioorg. Med. Chem.,18. 2894-2901 (2010).
  62. Onizuka K, Taniguchi Y., Sasaki S., A New Usage of Functionalized Oligodeoxynucleotide Probe for Site-SpecificModification ofa Guanine Base within RNA,Nucleic Acids Res.38, 1760-1766 (2010).

  63. Taniguchi Y., Uchida Y., Takaki T., Aoki E., Sasaki S., Recognition of CG interrupting site by W-shaped nucleoside analogs(WNA) having the pyrazole ring in an anti-parallel triplex DNA,Bioorg. Med. Chem.17, 6803-6810 (2009).
  64. Onizuka K.,Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification of RNA by functionality-transfer ODNprobes,NucleicAcids Symp. Ser.,53, 67-68 (2009).
  65. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S., Evaluation of theantisense effectofPEGylatedoligodeoxynucleotidescontaining intelligent nucleoside analogues,Nucleic Acids Symp. Ser., 53,167-168 (2009).
  66. Onizuka K, Taniguchi Y., Sasaki S., A New Odorless Procedure for the synthesis of 2'deoxy-6-thioguanosine and ItIncorporationInto Oligonucleotides,Nucleosides, Nucleotides, and Nucleic Acids, 28, 752-760 (2009).
  67. Onizuka K, Taniguchi Y., Sasaki S., Site-specific covalent modification of nucleic acids guided by functionality-transferoligodeoxynucleotidesBioconjugate Chem.20, 799-803 (2009).
  68. Ali M. M., Imoto S., Li Y., Sasaki S. Nagatsugi F., Incorporation of inducible nucleotide analog into DNA by DNApolymerases,Bioorg. Med. Chem.17, 2859-2863 (2009).
  69. Nasr T., Li Z., Nakagawa O., Taniguchi Y., Ono S., Sasaki S., Selective Fluorescence Quenching of the 8-OxoG-clamp by 8-Oxodeoxyguanosine in ODN,Bioorg. Med. Chem. Lett.,19, 727-730 (2009).

  70. Nagatsugi F., Nakahara R., Inoue K., Sasaki S., Synthesis and Evaluation of the Luciferase-Oligodeoxynucleotide fortheSequencse-Selective Detection of Nucleic Acids,Arch. Pharm. Chem. Life Sci.,341, 562-567 (2008).
  71. Onizuka K, Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification by functionality-transfer oligonucleotide with thephoto-inducible reactivity.Nucleic Acids Symp. Ser., 52, 367-368 (2008)
  72. Kurose Y., Taniguchi, Y., Nagatsugi F., Sasaki S., Synthesis of new nucleosides analogue connecting 2-amino-6-vinylpurinetothe 2’-deoxyribose skeletonviathe methylene linker.Nucleic Acids Symp., Ser.52, 43-44 (2008).
  73. Uchida Y., Taniguchi Y., Aoki E., Togo M., Sasaki S., Formation of a stable triplex incorporating a CG interrupting site by anewWNA derivative containing 3-aminopyrazole as a nucleobase.Nucleic Acids Symp. Ser., 52, 137-138 (2008).
  74. Brazier, J. A., Onishi I., Sasaki S., Binding of two bis-bipyridine minor groove binders to a DNA template in the presence ofCu2+ione.Nucleic Acids Symp. Ser., 52, 107-108 (2008).
  75. Taniguchi Y., Togo M., Aoki E., Uchida Y., Sasaki S., Synthesis of p-amino-WNA derivatives to enhance the stability of theanti-parallel triplex,Tetrahedron,64,7164-7170 (2008).
  76. Haruta Y., Onizuka K., Watanabe K., Kono K., Nohara A., Kubota K., Imoto S., Sasaki S., Stereoselective synthesis of (t)-2-deoxyolivin based on cycloaddition reaction between the homophthalic anhydride and the chiral cyclohexenone derivative,Tetrahedron,64, 7211-7218 (2008).

  77. Nasr T., Taniguchi Y., Sasaki S., Synthesis of 1’-Phenyl Substituted Nucleoside Analogs,Heterocycles,73, 2659-2668(2007).
  78. Nagatsugi F., Ogata Y., Imoto S., Sasaki S., Efficient Synthesis of 6-Substituted Purine Derivatives using Pd-CatalyzedCross-Coupling Reactions with 2’-Deoxyguanosine O6-Tosylate,Heterocycles,73, 493-501 (2007).
  79. Nagatsugi F., Nakayama S., Sasaki S., Development of the Novel Drug Releasing System Triggered by Hybridization withTargetSequence,Nucleosides, Nucleotides, and Nucleic Acids,26, 799-803 (2007).
  80. Nakagawa O., Ono S., Tsujimoto A., Li Z., Sasaki S., Selective Fluorescence Detection of 8-Oxoguanosine with 8-oxoG-clamp,Nucleosides, Nucleotides, and Nucleic Acids,26, 645-649 (2007).
  81. Imoto S., Ali M. M., Li Y., Sasaki S., Nagatsugi F., Enzymatic Incorporation of 2-Amino-6-Vinylpurine Derivative,NucleicAcidsSymp. Ser.,51, 357-358 (2007).
  82. Onizuka K., Taniguchi Y., Sasaki S., Development of novel thioguanosine analogs with the ability to specifically modifycytidine,Nucleic Acids Symp. Ser.,51, 5-6 (2007).
  83. Aoki E., Taniguchi Y., Sasaki S., Effective strand invasion ODN incorporating a new bicyclic nucleoside analogue (WNA),NucleicAcids Symp. Ser.,51, 255-256 (2007).
  84. Ono S., Li Z., Koga Y., Tsujimoto A., Nakagawa O., Sasaki S., Development of a Specific Fluorescent Probe for 8-Oxoguanosine,Nucleic Acids Symp. Ser.,51, 315-316 (2007).
  85. Taniguchi Y., Kool E. T., Syntheses and properties of low-polarity shape mimics of 8oxopurines,Nucleic Acids Symp. Ser.,51,217-218 (2007).
  86. Taniguchi Y., Kool E. T., Nonpolar Isosteres of Damaged DNA Bases: Effective Mimicry of Mutagenic Properties of 8-Oxopurines,J. Am. Chem. Soc.,129, 8836-8844 (2007).
  87. Uzu T., Sasaki S., A New Copper(II) Complex as an Efficient Catalyst of Luminol Chemiluminescence,Organic Lett.,9, 4383-4386 (2007).
  88. Alam Md., Majumdar A., Thazhathveetil A., Liu S.-T., Liu J.-Lan., Puri N., Cuenoud B., Sasaki S., Miller P., Seidman M.,Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo,Biochemistry,46, 10222-10233 (2007).
  89. Nakagawa O., Ono S., Li Z., Tsujimoto A., Sasaki S., Specific Fluorescent Probe for 8-Oxoguanosine,Angew. Chem. Int.Ed.,46,4500-4503 (2007).
  90. Tsujita S., Tanada M., Kataoka T.,Sasaki S., Equilibrium shift by target DNA substrates for determination of DNA bindingligands,Bioorg. Med. Chem. Lett.,17, 68-72 (2007).

  91. Nakayama S., Nagatsugi F., Sasaki S., Novel drug releasing system triggered by hybridization with target sequence,NucleicAcids Symp. Ser.,50, 143-144 (2006).
  92. Kataoka T., Tanada M., Onishi I., Sasaki S., Recognition of DNA with assembly of minor groove binders mediated bymetalcomplexation,Nucleic Acids Symp. Ser.,50, 161-162 (2006).
  93. Aoki E., Taniguchi Y., Togo M., Sasaki S., Effects of the modified aromatic ring of WNA on stability of triplex DNA,NucleicAcidsSymp. Ser.,50, 185-186 (2006).
  94. Nakagawa O., Ono S., Tsujimoto A., Li Z., Sasaki S., Fluorescence detection of 8-oxoguanosine by G-clamp derivatives,NucleicAcids Symp. Ser.,50, 21-22 (2006).
  95. Sasaki S., Nagatsugi F., Application of unnatural oligonucleotides to chemical modification of gene expression,Current Opin.Chem. Biol.,10, 615-621 (2006).
  96. Tanada M., Tsujita S., Kataoka T., Sasaki S., Cu2+-Mediated Assembly of the Minor Groove Binders on the DNA TemplatewithSequence Selectivity,Organic Lett.,8, 2475-2478 (2006).
  97. Ali M. M., Oishi M., Nagatsugi F., Mori K., Nagasaki Y., Kataoka K., Sasaki S., Intracellular Ability of an InducibleAlkylationSystem to Exhibit Antisense Effects with Greater Potency and Selectivity,Angew. Chem. Int. Ed.,45, 3136-3140(2006).
  98. Taniguchi Y., Nakamura A., Senko Y., Nagatsugi F., Sasaki S., Effects of Halogenated WNA Derivatives onSequenceDependency for Expansion of Recognition Sequences in the Non-Natural Type Triplexes,J. Org. Chem.,71, 2115-2122(2006).
  99. Ali M. M., Nagatsugi F., Sasaki S., Nakahara R., Maeda M., Application of 2-Amino-6-Vinylpurine as an Efficient AgentforConjugation of Oligonucleotides,Nucleosides, Nucleotides, and Nucleic Acids,25, 159-169 (2006).
  100. Tanada M., Tsujita S., Sasaki S., Design of New Bidentate Ligands Constructed of Two Hoechst 33258 Units forDiscrimination ofthe Length of Two A3T3 Binding Motifs,J. Org. Chem.,71, 125-134 (2006).

  101. Yamada Y., Kogure K., Nakamura Y., Inoue K., Akita H., Nagatsugi F., Sasaki S., Suhara T., Harashima H., Developmentofefficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure,Biol. Pharm.Bull.,28, 1939-1942 (2005).
  102. Sasaki S., Nagatsugi F., Ali M. M., Mori S., Nakayama S., Molecular Design for DNA Hybridization-Promoted ReactionswithHigh Efficiency and Selectivity,Collection Symposium Series,7, 115-126 (2005).
  103. Ali M. M., Nagatsugi F., Nakayama S., Alam M. R., Kawasaki T., Sasaki S., Design of highly efficient and selectivetransferreaction of nitrosyl group to dC and dMC resulting in specific deamination,Nucleosides, Nucleotides, and Nucleic Acids,24,721-724 (2005).
  104. Taniguchi Y., Nakamura A., Senko Y., Kodama K., Nagatsugi F., Sasaki S., Expansion of triplex recognition codes by theuseof novel bicyclic nucleoside derivatives (WNA),Nucleosides, Nucleotides, and Nucleic Acids,24, 823-827 (2005).
  105. Tanada M., Sasaki S., Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groovebinders,Nucleic Acids, Symp. Ser.,49, 1-2 (2005).
  106. Taniguchi Y., Nakamura A., Aoki E., Sasaki S., Modification of the aromatic ring of the WNA analogues for expansion ofthetriplex recognition codes,Nucleic Acids, Symp. Ser.,49, 173-174 (2005).
  107. Nagatsugi F., Mori S., Ali M. M., Ogata Y., Sasaki S., Substituent effects on the in situ activation of the double activatedcross-linking reaction,Nucleic Acids, Symp. Ser.,49, 175-176 (2005).
  108. Oishi M., Nagatsugi F., Sasaki S., Nagasaki Y., Kataoka K., Smart Polyion Complex Micelles for Targeted IntracellularDeliveryof PEGylated Antisense Oligonucleotide with Acid-Labile Linkage,Chembiochem,6, 718-725 (2005).
  109. Kawasaki T., Nagatsugi F., Ali, M. M., Maeda M., Sugiyama K., Hori K., Sasaki S., Hybridization-Promoted and Cytidine-Selective Activation for Cross-Linking with the Use of 2-Amino-6-Vinylpurine Derivatives,J. Org. Chem.,70, 14-23 (2005).

  110. Taniguchi Y., Nakamura A., Senko Y., Sasaki S., Effects of 5-substituted pyrimidine nucleoside bases of WNA on stabilityoftriplex DNA,Nucleic Acids, Symp. Ser.,48, 69-70 (2004).
  111. Ali M. M., Nagatsugi F., Oishi M., Nagasaki Y., Kataoka K., Sasaki S., Synthesis and evalutaion of thefunctionaloligonucleotides-PEG conjugates,Nucleic Acids, Symp. Ser.,48, 61-62 (2004).
  112. Nagatsugi F., Nakayama S., Ali M. M., Sasaki S., Selective nitrosyl group transfer reaction to cytidine usingoligonucleotidesbearing S-nitrosothioguanosine,Nucleic Acids, Symp. Ser.,48, 23-24 (2004).
  113. Imoto S., Haruta Y., Watanabe K., Sasaki S., New DNA Binding Ligands as a Model of Chromomycin A3,Bioorg. Med.Chem.Lett.,14, 4855-4859 (2004).
  114. Ali M. M., Alam M. R., Kawasaki T., Nakayama S., Nagatsugi F., Sasaki S., Sequence- and Base-Specific Delivery ofNitricOxide to Cytidine and 5-Methylcytidine Leading to Efficient Deamination,J. Am. Chem. Soc.,126, 8864-8865 (2004).
  115. Sasaki S., Kurosaki F., Haradahira T., Yamamoto F., Maeda J., Okauchi T., Suzuki K., Suhara T., Maeda M., Synthesis of11C-Labeled Bis(phenylalkyl)amine and Their in Vitro and in Vivo Binding Properties in Rodent and Monkey Brains,Biol.Pharm.Bull.,27, 531-537 (2004).
  116. Nagatsugi F., Sasaki S., Chemical Tools for Targeted Mutagenesis of DNA Based on Triple Helix Formation.,Biol. Pharm.Bull.,27, 463-467 (2004).
  117. Sasaki S., Taniguchi Y., Takahashi R., Senko Y., Kodama K., Nagatsugi F., Maeda M., Selective Formation of StableTriplexesIncluding a TA or a CG Interrupting Site with New Bicyclic Nucleoside Analogues (WNA),J. Am. Chem. Soc.,126,516-528 (2004).
  118. Tanada M., Shibata Y., Maeda, M., Sasaki S., Bipyrrole derivatives as new DNA-minor groove binders,Heterocycles,63, 29-39(2004).

  119. Oishi M., Sasaki S., Nagasaki Y., Kataoka K., pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol)conjugatethrough acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation,Biomacromolecules,4,1426-32 (2003).
  120. Yamamoto F., Kuwano E., Kaneshiro T., Sasaki S., Maeda M., 125I-Labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: synthesis and preliminary tissue distribution.,J. Labelled Cpd. Radiopharm.,43,737-750(2003).
  121. Tokiwa H., Sera N., Fukuhara K., Utsumi H., Sasaki S., Miyata N., Structural activity relationship between Salmonella-mutagenicity and nitro-orientation of nitroazaphenanthrenes,Chemico-Biological Interactions,146, 19-25 (2003).
  122. Taniguchi Y., Senko Y., Kodama K., Nakamura A., Sasaki S., Design and evaluation of novel nucleoside analogs (WNA)forspecific formation of non-natural type triplexes containing a TA or CG interrupting site.,Nucleic Acids Res. Suppl.,3, 113-114(2003).
  123. Fuchigami T., Haradahira T., Arai T., Okauchi T., Maeda J., Suzuki K., Yamamoto F., Suhara T., Sasaki S., Maeda M.,Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: An N-methyl-D-aspartate (NMDA)receptorantagonist,Biolog. Pharm. Bull.,26, 1570-1573 (2003).
  124. Nagatsugi F., Suenaga Y., Sasaki S., Efficient cross-linking reactions by functional nucleobases capable of in situactivationunder neutral conditions,Nucleic Acids Res. Suppl.,3, 155-156 (2003).
  125. Kundu M., Nagatsugi F., Majumdar A., Miller P. S., Seidman M. M., Enhancement and inhibition by 2'-O-hydroxyethylresiduesof gene targeting mediated by triple helix forming oligonucleotides.,Nucleosides Nucleotides Nucleic Acids,22,1927-38 (2003).
  126. Nagatsugi F., Sasaki S., Miller P. S., Seidman M. M., Site-Specific Mutagenesis by Triple-Helix FormingOligonucleotidesContaining a Reactive Nucleoside Analogue,Nucleic Acids Res.,31, e31 (2003).

  127. Nagatsugi F., Matsuyama Y., Maeda M., Sasaki S., Selective cross-linking to the adenine of the TA interrupting site withinthetriple helix,Bioorg. Med. Chem. Lett.,12, 487-9 (2002).
  128. Nagatsugi F., Sasaki S., Miller P. S. and Seidman M.M. A new reactive nucleoside analogue for highly reactive andselectivecross-linking reaction to cytidine under neutral conditions.Nucleic Acids Res. Suppl.,2, 31-32 (2002).
  129. Ali M. M, Nagatsugi F., Yamamoto F., Maeda M., Sasaki S., 2-Amino-6-Vinylpurine as a Tool of Post Synthetic ConjugationofOligonucleotides with Radio-, Spin-, Fluorescence Label and Peptides,Nucleic Acids Res. Suppl.,2, 149-150(2002).
  130. Yosuke Taniguchi, Ryo Takahashi, Keiichi Kodama, Yusuke Senko, Minoru Maeda and Shigeki Sasaki, Selective formationofnon-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA)analogs,Nucleic Acids Res. Suppl.,2, 34-35 (2002).

  131. F. Nagatsugi, D.Usui, T. Kawasaki, M. Maeda, S. Sasaki, Selective Reaction to a Flipping Cytidine of the Duplex DNAMediatedby Triple Helix Formation,Bioorg. Med. Chem. Lett,11, 343-345 (2001).
  132. Fumi Nagatsugi, Natsuko Tokuda, MinoruMaeda and Shigeki Sasaki, A new reactive nucleoside analogue for highly reactiveandselective cross-linking reaction to cytidine under neutral conditions,Bioorg. Med. Chem. Lett., 11, 2577-2579 (2001).
  133. Shigeki Sasaki, Hiroyuki Yamauchi, Fumi Nagatsugi, Ryo Takahashi, Yosuke Taniguchi and Minoru Maeda, W-shapenucleicacid (WNA) for selective formation of non-natural anti-parallel triplex including a TA interrupting site,TetrahedronLett.,426915-6918(2001).
  134. F. Nagatsugi, T. Kawasaki, N. Tokuda, M. Maeda, S. Sasaki, Site-Directed Alkylation to cytidine within Duplex bytheOligonucleotides Containing Functional Nucleobases, Nucleoside,Nucleotides & Nucleic Acids, 20, 915-919 (2001).
  135. Sasaki, Shigeki; Shibata, Takayuki; Torigoe, Hidetaka; Shibata, Yoshihiro; Minoru, Maeda, Novel Class of DNA BindingMotifsBased on Bistetrahydrofuran and Bisfuran Skeleton with Long Alkyl Chains,Nucleoside, Nucleotides and NucleicAcids,20, 551-558 (2001).
  136. Fumi Nagatsugi, Natsuko Tokuda, Minoru Maeda and Shigeki Sasaki, Efficient cross-linking to cytidine under neutralconditionsusing the 2-amino-6-vinylpurine derivative having an additional activating group,Nucleic Acids Res. Suppl.1, 87-88(2001).
  137. Sasaki, Shigeki; Ehara, Takeru; Sakata, Ikuhiro; Fujino, Yasuhiro; Harada, Naozumi; Kimura, Junko; Nakamura, Hideo;MaedaMinoru, Development of Novel Telomerase Inhibitors Based on a Bisndole Unit,Bioorg. Med. Chem. Lett.,11, 583-585 (2001).
  138. S,Sasaki, H. Yamauchi, R. Takahashi, Y. Taniguchi M. Maeda, New base analogs for the formation of non-natural triplexes,Nucleic Acids Res. Suppl.1, 23-24 (2001).
  139. S,Sasaki, Active Oligonucleotides Incorporating Alkylating Agent as Potential Sequence- and Base Selective Modifier ofGeneExpression, Eur.J. Phar. Sci.13, 43-51 (2001).
  140. Sasaki S., Kanda T., Ishibashi N., Yamamoto F., Haradahira T., Okauchi T., Maeda J., Suzuki K., Maeda M., 4,5,9,10-Tetrahydro-1,4-Ethanobenz[b]quinolizine as a Prodrug for Its Quninolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors,Bioorg. Med. Chem. Lett.,11, 519-521(2001).
  141. Haradahira T., Zhang M., Maeda J.,Okauchi T., Kida T., Kawabe K., Sasaki S., Suhara T., Suzuki K., A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeledanalog,Chem. Pharm. Bull.,49, 147-150 (2001).
  142. Sasaki S., Ehara T., Alam M. R., Fujino Y., Harada N., Kimura J., Nakamura H., Maeda M., Solid-Phase Synthesis of aLibraryConstructed of Aromatic Phosphate, Long Alkyl Chains and Tryptophane Components, and Identification of PotentDipeptideTelomerase Inhibitors,Bioorg. Med. Chem. Lett.11, 2581-2584(2001).
  143. 黒崎文枝、佐々木茂貴、原田平輝志、前田純、岡内隆、張明栄、川辺光一、須原哲也、前田稔、11C標識NMDA/NR2Bサブユニット選択的なPETリガンドの合成とインビトロ・インビボ脳内分布、核医学38,596 (2001).

  144. Alam M. R., Maeda M., Sasaki S., DNA-Binding Peptides Searched from the Solid-Phase Combinatorial Library with theUse ofthe Magnetic Beads Attaching the Target Duplex DNA,Bioorg. Med. Chem.,8, 465-473 (2000).
  145. Ishibashi N., Kuwamura T., Sano H., Yamamoto F., Haradahira T., Suzuki K., Suhara T., Sasaki S., Maeda M., SynthesisandEvaluation of New 18F- and 11C-Labelled 6,11-Ethanobenzo[b]quinolizinium Derivatives for Imaging of the NMDAReceptor at theTCP-Binding Site,J. Labelled. Cpd. Radiopharm.,43, 375-383(2000).

  146. Nagatsugi, F., Kawasaki T., Usui D., Maeda M., Sasaki S., Highly Efficient and Selective Cross-Linking to Cytidine Basedon theNew Strategy for Auto-Activation within Duplex ,J. Am. Chem. Soc.,121, 6753-6754 (1999).
  147. Matsuura N., Yashiki Y., Nakashima S., Maeda M., Sasaki S., Shortcut Stereoselective Synthesis of 1-b-Alkyl-2-DeoxyriboseDerivatives via Wittig-Horner-Emons Reaction,Heterocycles,51, 975-978 (1999).
  148. Sasaki S., Nagatsugi F., Maeda M., 2-Deoxy Nucleoside Derivatives off 6-Substituted 2-Aminopurine as Highly EfficientandSelective Cross-Linking Agent to Cytidine,Coll. Czech. Chem. Commun., Symp. Series,2, 114-118 (1999).
  149. Shibata T., Torigoe H., Shibata Y., Maeda M., Sasaki S., Novel DNA-Binding Ligands with Sequence Selectivity BasedonHydrophobic Structure,Nucleic Acids., Symp. Ser.,42, 251-252 (1999).
  150. Kawasaki T., Nagatsugi F., Usui D., Maeda M., Sasaki S., Efficient cross-linking to cytidine by functional nucleobasescapableof in situ activation,Nucleic Acids., Symp. Ser.,42, 43-44 (1999).
  151. Alam M. R., Maeda M., Sasaki S., DNA Binding Affinity of Pentapeptides Selected from Combinatorial Library,NucleicAcids.,Symp. Ser.,42, 173-174 (1999).
  152. Sakata K., Hamase K., Sasaki S., Maeda M., Zaitsu K., Reversible Fluorescence Derivatization of Amino GroupsUsingDansylaminomethylmaleic Acid via Its Anhydride,Anal. Sci.,15, 1095-1099 (1999).

  153. Sasaki S., Maruta K., Naito H., Maemura R., Kawahara E., Maeda M., In Vitro Antitumor Activities of NewSyntheticBistetrahydrofuran Derivatiaves as Analogs of Annonaceous Acetogenins,Chem. Pham. Bull.,46, 154-158 (1998).
  154. Sasaki S., Maruta K., Naito H., Maemura R., Kawahara E., Maeda M., Novel Acyclic Ligands for Metal Cations Based ontheAdjacent Bistetrahydrofuran as Analogs of NaturalANNONACEOUSAcetogenins,Tetrahedron,54, 2401-2410 (1998).
  155. 松井晶子、高橋司、松尾浩民、佐々木茂貴、前田稔、澤田康文、アミオダロンをはじめとする抗不整脈薬などによる薬剤性パーキンソニズムの基礎的研究、Progress in Medicine, Vol. 18, suppl. 1, 612-616 (1998).
  156. Matsui A., Matsuo H., Takanaga H., Sasaki S., Maeda M., Sawada Y., Prediction of Catalepsies Induced by Amiodarone,Aprindine and Procaine-Similarity in Conformation of Diethylaminoethyl Side Chain,J. Pharmacol. ExperimentalTherapeutics,287,725-732 (1998).
  157. Sasaki S., Hashimoto T., Obana N., Yasuda H., Uehara, Y., Maeda M., Design of New Inhibitors for CDC2 Kinase Based onaMultiple Pseudosubstrate Structure,Bioorg. Med. Chem. Lett.,8, 1019-1022 (1998).
  158. Nagatsugi F., Kawasaki T., Tanaka Y., Maeda M., Sasaki S., Structural analysis of cross-linked addeucts withtheoligonucleotides incorporating 2-amino-6-vinylpurineNucleic Acids, Symp. Ser.,39, 103-104 (1998).
  159. Alam, M. R., Tanaka Y., Maeda M., Sasaki S., Random search of new peptide ligands towards duplex DNA by theapplication ofcombinatorial technology,Nucleic Acids, Symp. Ser.,39, 69-70 (1998).
  160. Sasaki, S., Ishibashi N., Kuwamura T., Sano H., Matoba M., Nisikawa, T., Maeda M., Excellent Acceleration of the Diels-AlderReaction by Microwave Irradiation for the Synthesis of New Fluorine-Substituted Ligands of NMDA Receptor,Bioorg.Med.Chem.Lett.,8, 2983-2986 (1998).
  161. Haradahira T. Sasaki S. Maeda M. Kobayashi K. Inoue O. Tomita U. Nishikawa T. Suzuki K.; Synthesis and BrainDistribution ofCarbon-11 Labeled Analogs of Antagonists for the NMDA Receeptor Coupled PCP-Binding Site.J. Labelled.Cpd. Radiopharm.,41, 843-858 (1998).

  162. Nagatsugi F., Uemura K., Nakashima S., Maeda M., Sasaki S., 2-Aminopurine Derivatives with C6-Substituted Olefin asNovelCross-Linking Agents and the Synthesis of the Corresponding b-Phosphoramidite Precursors,Tetrahedron,53, 3035-3044 (1997).
  163. Nakashima S., Matsuura N., Nagatsugi F., Maeda M., Sasaki S., Synthesis and Evaluation of OligonucleotidesIncorporatingNovel Artificial Nucleobases for the Selective Formation of Non-Natural Type Triplexes,Nucleic Acids, Symp.Ser.,37, 33-34 (1997).
  164. Nagatsugi F., Kawasaki T., Maeda M., Sasaki S., Novel Cross-Linking Reaction of Oligonuceotides Incorporating NewBaseAnalogs with Selective Reactivity towad Cytidine,Nucleic Acids, Symp. Ser.,37, 67-68 (1997).
  165. Nagatsugi F., Uemura K., Nakashima S., Maeda M., Sasaki S., 2-Aminopurine Derivatives with C6-Substituted Olefin asNovelCross-Linking Agents and the Synthesis of the Corresponding b-Phosphoramidite Precursors,Tetrahedron,53, 3035-3044 (1997).
  166. Nakashima S., Matsuura N., Nagatsugi F., Maeda M., Sasaki S., Synthesis and Evaluation of OligonucleotidesIncorporatingNovel Artificial Nucleobases for the Selective Formation of Non-Natural Type Triplexes,Nucleic Acids, Symp.Ser.,37, 33-34 (1997).
  167. Nagatsugi F., Kawasaki T., Maeda M., Sasaki S., Novel Cross-Linking Reaction of Oligonuceotides Incorporating NewBaseAnalogs with Selective Reactivity towad Cytidine,Nucleic Acids, Symp. Ser.,37, 67-68 (1997).

  1. Yosuke Taniguchi and Shigeki Sasaki, 「DEvelopment of Triplex Forming Oligonucleotide Including Artificial NucleosideAnalogues for the Antigene Strategy」、Springer, Synthesis of Therapeutic Oligonucleotides p253-270 (2018)
  2. 遺伝子医学MOOK 32号  「難病研究up-to-date  -臨床病態解析と新たな診断・治療法開発をめざして-」 第3章 難病の治療法(総論)3.核酸医薬   佐々木 茂貴、2017年12月、メディカルドゥ出版
  3. CSJ Current Review医療・診断・創薬の化学 医療分野に挑む革新的な化学技術第10章 バイオ医薬品(抗体医薬・核酸医薬)の最前線、佐々木 茂貴、2017年09月、日本化学会
  4. スタンダード薬学シリーズII 3 II 生体分子・医薬品の化学による理解、佐々木 茂貴、2016年03月、日本薬学会 
  5. 核酸医薬の創製と応用展開 第6章 インテリジェント人工核酸―クロスリンク核酸・官能基転移核酸― 佐々木 茂貴、2016年02月、シーエムシー出版
  6. Shigeki Sasaki, Yosuke Taniguchi, Fumi Nagatsugi, 「SpecificRecognition of Single Nucleotide by AlkylatingOligonucleotidesand Sensing of8-Oxoguanine」、Springer, 31, 221-248 (2016)
  7. 中川治、佐々木茂貴 「核酸をトリガーとする増幅反応」、化学、化学同人、60、70-71(2005)
  8. 谷口陽祐、佐々木茂貴 「3本鎖DNA認識コード拡張のための人工ヌクレオシドの開発」、有機合成化学協会誌、62、1026-1037(2004)
  9. 佐々木茂貴 「ゲノムケミストリー」(関根光雄、齋藤烈 編)、第2章ゲノムに機能する人工核酸、2.6ゲノムクロスリンク能をもつ人工核酸、講談社、東京、89-100(2003)
  10. 佐々木茂貴 「インテリジェント材料・技術の最新開発動向、インテリジェント機能性核酸の創製」、シーエムシー出版(2003)
  11. 佐々木茂貴、永次史 「遺伝子発現機構を標的とする核酸医薬品の新しい化学」、ファルマシア(2003)
  12. 佐々木茂貴 「ゲノム標的化学遺伝子に働くロボットを目指して」、日本化学会生体機能関連化学部会ニュースレター、17、101-104(2003)
  13. 佐々木茂貴 「放射薬品化学」、第5章標識化合物の合成、廣川書店、東京(1999)
  14. 佐々木茂貴 「3本鎖DNA形成による遺伝子発現の化学的制御(アンチジーン法)のための分子設計」、有機合成化学協会誌、55、590-599(1997)
  15. 佐々木茂貴 「コンビナトリアルケミストリー」、蛋白質表面認識分子探索のためのコンビナトリアルテクノロジーの応用−水溶液中での小さなペプチド同士の強い相互作用の検索−、化学同人、京都、99-101(1997)