Graduate School of Pharmaceutical Sciences, Kyushu University
Bioorganic and Synthetic Chemistry









Publication List (2014-1997)

  1. Fuchi Y. and Sasaki S.*, Efficient Covalent Capture of 8-Nitroguanosine via a Multiple Hydrogen-Bonded. Org. Lett. doi:10.1021/ol500452r
  2. Goto T., Shiina A., Murata T., Tomii M., YamazakiT., Yoshida K., Yoshino T., Suzuki O., Sogawa Y., Mizukami K., Takagi N.,Yoshitomi T., Etori M., Tsuchida H., Mikkaichi T., Nakao N., Takahashi M., Takahashi H, Sasaki S. Identification of the5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highlyselective PDE4B inhibitors Bioorg. Med. Chem. Lett., 24(3), 893-899 (2014) DOi: 10.1016/j.bmcl.2013.12.076
  3. Yizhen Y., Taniguchi Y.* and Sasaki S.*, Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its base pairing properties. Tetrahedron, doi: 10.1016/j.tet.2014.01.047.
  4. Taniguchi Y.*, Fukabori K., Kikukawa Y., Koga Y and Sasaki S.*,2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dG in DNA.  Bioorg. Med. Chem. DOI:http://dx.doi.org/10.1016/j.bmc.2014.01.024
  5. Taniguchi Y., Koga Y., Shigeki Sasaki*. Synthesis of 8-oxoguanosine phosphoramidite and its incorporation into oligoribonucleotides. Current Protocols in Nucleic Acid Chemistry,


                               Org. Lett.
     
                         Bioorg. Med. Chem.                                                                  Tetrahedron

  6. Sasaki H. and Sasaki S*. B-Z Transition of (dA-T)n Duplex Induced by Spermine Porphyrin-Conjugate via anIntermediate DNA Conformation. Chem. Comm.,49(79) 9024-9026(2013)  DOI: 10.1039/C3CC45213A  
  7. Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N.,Takahashi M., Hasegawa M. and Sasaki S. Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidinederivatives as novel and potent PDE4 inhibitors. Bioorg. Med. Chem.  21 (22) 7025-7037 (2013). DOI: http://dx.doi.org/10.1016/j.bmc.2013.09.013
  8. Tsuji G,, Kawakami K and Sasaki S*. Enantioselective Binding of Chiral 1,14-Dimethyl[5]Helicene-spermine Ligands with B- and Z-DNA. Bioorg. Med. Chem.  21 (19) 6063-6068 (2013). DOI: http://dx.doi.org/10.1016/j.bmc.2013.07.022
  9. Okamura H, Taniguchi Y* and Sasaki S*. N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits a selective recognition of a CG interrupting site for the formation of anti-parallel triplexes, Org. Biomol. Chem., 11. 3918-3924 (2013) DOI: 10.1039/C3OB40472B
  10. Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N., TakahashiM., Hasegawa M. and Sasaki S. Identification of the fused bicyclic4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorg. Med. Chem. Lett., 23(11), 3325-3328 (2013) DOI: http://dx.doi.org/10.1016/j.bmcl.2013.03.104
  11. Nishimoto A., Jitsuzaki D., Onizuka K., Taniguchi Y., Nagatsugi F. and Sasaki S*. 4-Vinyl-Substituted Pyrimidine Nucleosides Exhibit the Efficient and SelectiveFormation of Interstrand Cross-Links with RNA and duplex DNA, Nucleic Acids Res.,41(13) 6774-6781 (2013) DOI: 10.1093/nar/gkt197  
  12. Koga Y., Taniguchi Y and Sasaki S*. Synthesis of the Oligoribonucleotides Incorporating 8-Oxo-guanosine and Evaluation of their Base Pairing Properties,  Nucleosides, Nucleotides and Nucleic Acids, 32(3), 124-136. (2013) DOI: 10.1080/15257770.2013.767461
  13. Taniguchi Y., Okamura H., Fujino N., Sasaki S*. Synthesis of 1'-phenyl-2-OMe ribose analogues connecting the thymine base at the 1' position through a flexible linker for the formation of a stable anti-parallele triplex DNA, Tetrahedron, 69(2), 600-606 (2013)DOI: 10.1016/j.tet.2012.11.016  


                                Chem. Comm.    
       
                           Org. Biomol. Chem                                                               Bioorg. Med. Chem.
           
                                 Nucleic Acids Res.                        Nucleosides, Nucleotides and Nucleic Acids
                 
                                    Tetrahedron                                                

  14. Nasr T, Taniguchi Y., Takaki T., Okamura H., Sasaki S*. Properties of Oligonucleotidewith Phenyl-Substituted Carbocyclic Nucleoside Analogues for the Formation ofDuplex and Triplex DNA, Nucleosides, Nucleotides and Nucleic Acids, 31(12), 8441-860. (2012) DOI: 10.1080/15257770.2012.737970.
  15. Taniguchi Y* and Sasaki S*., An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin gene with triplex forming oligonucleotides containing a W-shaped nucleoside analogue (WNA-bT), Org. Biomol. Chem., 10(41), 8336-8341. (2012) DOI: 10.1039/c2ob26431e
  16. Aoki E., Taniguchi Y., Wada Y., Sasaki S*, Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-bT) containing an ortho-methyl-substituted phenyl ring, ChemBioChem,. 13(8), 1152-1160 (2012) DOI: 10.1002/cbic.201200066
  17. Abe Y., Nakagawa O., Yamaguchi R., Sasaki S.*, Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site, Bioorg. Med. Chem. 20(11), 3470-3479 (2012). DOI: 10.1016/j.bmc.2012.04.009.
  18. Onizuka K., Nishioka T., Li Z., Jitsuzaki D., Taniguchi Y. and Sasaki S.*, Aneficient and simple method for site-selective modification of O6-methyl-2'-deoxyguanosine in DNA, ,Chem. Comm.,48 (33), 3969-3971. DOI: 10.1039/c2cc17621a
  19. Sasaki S.*, Onizuka K., Taniguchi Y., Oligonucleotide containing S-Functionalized 2'-deoxy-6-thioguanosine: Facile Tools for Base-Selective and Site Specific Internal Modification of RNA, Current Protocols in Nucleic Acid Chemistry, 4.49.1-4.49.16 (2012) DOI: 10.1002/0471142700.nc0449s.48
  20. Taniguchi Y, Koga Y, Fukabori K, Kawaguchi R, Sasaki S.*, OFF-to-ON type fluorescent probe for the detection of 8-oxo-dG in DNA by the Adap-masked ODN probe, Bioorg. Med. Chem. Lett., 22(1), 543-546 (2012) DOI: 10.1016/j.bmcl.2011.10.093.

         
                      Org. Biomol. Chem                                          Nucleosides, Nucleotides and Nucleic Acids
           
                            Chem. Comm.                      ChemBioChem                        Bioorg. Med. Chem.
     
                     Bioorg. Med. Chem. Lett.                                          

  21. Sasaki S., Onizuka K. and Taniguchi Y, The oligodeoxynucleotide probes for the site-specific modification of RNA,Chem.Soc.Rev.,40(12), 5698-5706 (2011) DOI: 10.1039/c1cs15066a.
  22. Taniguchi Y, Kawaguchi R, Sasaki S., Adenosine-1,3-diazaphenoxazine Derivative for Selective Base Pair Formation with 8-Oxo-2'-deoxyguanosine in DNA, J. Am. Chem. Soc., 133, 7272-7275 (2011). DOI: 10.1021/ja200327u.  
  23. Koga Y, Fuchi Y, Nakagawa O, Sasaki S., Optimization of Fluorescence Property of the 8-OxodGclamp Derivative for Better Selectivity for 8-Oxo-2'-deoxyguanosine, Tetrahedron, 67, 6746-6752 (2011). DOI: 10.1016/j/.tet.2011.03.111,
  24. Onizuka K, Shibata A, Taniguchi Y, Sasaki S., Pin-Point Chemical Modification of RNA with DiverseMolecules through the Functionality Transfer Reaction and Copper-CatalyzedAzide-Alkyne Cycloaddition Reaction,Chem. Comm., 47(17), 5004-5006 (2011). DOI: 10.10389/C1CC10582E,

     
                   Chem. Soc. Rev.

               
              J. Am. Chem. Soc                                    Tetrahedron                   Chem. Comm.

  25. Taniguchi Y., Nitta A., Park S. M., Kohara A., Uzu T., Sasaki S., The ODN probes conjugating the Cu(II) complex enhance the luminol chemiluminescense by assembling on the DNA template, Bioorg. Med. Chem. 18, 8614-8617 (2010).
  26. Doi I., Tsuji G., Kawakami K., Nakagawa O., Taniguchi Y., Sasaki S., The Spermine-Bisaryl Conjugate as a Potent Inducer for the B to Z-DNA Transition, Chem. Eur. J.16, 11993-11999 (2010).  
  27. Imoto S., Hori T., Hagihara, S., Taniguchi Y., Sasaki S., Nagatsugi F., Alteration of Cross-linking Selectivity with the 2'-OMe Analogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense Effect Bioorg. Med. Chem. Lett., 20, 6121-6124 (2010).
  28. Onizuka K., Taniguchi Y., Sasaki S., Activation and Alteration of Base Selectivity by Metal Cations in the Functionality-Transfer Reaction for RNA Modification, Bioconjugate Chem. 21, 1508-1512 (2010).
  29. Nagatsugi F., Sasaki S., Synthesis of Reactive Oligonucleotides foe Gene Targeting and Their Application to Gene Expression Regulation, Bull. Chem. Soc. Jpn., 83, 744-755 (2010)
  30. Li Z, Nakagawa O, Koga Y, Taniguchi Y., Sasaki S., Synthesis of New Derivatives of 8-oxoG-Clamp for Better Understanding the Recognition Mode and Improvement of Selective AffinityBioorg. Med. Chem.18, 3992-3998 (2010).
  31. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S.,  The Alkyl-Connected 2-Amino-6-Vinylpurine (AVP) Crosslinking Agent for Improved Selectivity to the Cytosine, Bioorg. Med. Chem., 18. 2894-2901 (2010).
  32. Onizuka K, Taniguchi Y., Sasaki S., A New Usage of Functionalized Oligodeoxynucleotide Probe for Site-SpecificModification of a Guanine Base within RNA, Nucleic Acids Res.38, 1760-1766 (2010).  

  33. Taniguchi Y., Uchida Y., Takaki T., Aoki E., Sasaki S., Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA, Bioorg. Med. Chem.17, 6803-6810 (2009).  
  34. Onizuka K.,Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification of RNA by functionality-transfer ODNprobes,NucleicAcids Symp. Ser.,53, 67-68 (2009).  
  35. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S., Evaluation of theantisense effect of PEGylatedoligodeoxynucleotidescontaining intelligent nucleoside analogues,Nucleic Acids Symp. Ser., 53,167-168 (2009).  
  36. Onizuka K, Taniguchi Y., Sasaki S., A New Odorless Procedure for the synthesis of 2'deoxy-6-thioguanosine and It Incorporation Into Oligonucleotides, Nucleosides, Nucleotides, and Nucleic Acids, 28, 752-760 (2009).  
  37. Onizuka K, Taniguchi Y., Sasaki S., Site-specific covalent modification of nucleic acids guided by functionality-transfer oligodeoxynucleotides Bioconjugate Chem. 20, 799-803 (2009).
  38. Ali M. M., Imoto S., Li Y., Sasaki S. Nagatsugi F., Incorporation of inducible nucleotide analog into DNA by DNA polymerases, Bioorg. Med. Chem.17, 2859-2863 (2009).
  39. Nasr T., Li Z., Nakagawa O., Taniguchi Y., Ono S., Sasaki S., Selective Fluorescence Quenching of the 8-OxoG-clamp by 8-Oxodeoxyguanosine in ODN, Bioorg. Med. Chem. Lett., 19, 727-730 (2009).

  40. Nagatsugi F., Nakahara R., Inoue K., Sasaki S., Synthesis and Evaluation of the Luciferase-Oligodeoxynucleotide for the Sequencse-Selective Detection of Nucleic Acids, Arch. Pharm. Chem. Life Sci., 341, 562-567 (2008).
  41. Onizuka K, Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity. Nucleic Acids Symp. Ser., 52, 367-368 (2008).
  42. Kurose Y., Taniguchi, Y., Nagatsugi F., Sasaki S., Synthesis of new nucleosides analogue connecting 2-amino-6-vinylpurine to the 2’-deoxyribose skeleton via the methylene linker. Nucleic Acids Symp., Ser. 52, 43-44 (2008).
  43. Uchida Y., Taniguchi Y., Aoki E., Togo M., Sasaki S., Formation of a stable triplex incorporating a CG interrupting site by a new WNA derivative containing 3-aminopyrazole as a nucleobase. Nucleic Acids Symp. Ser., 52, 137-138 (2008).
  44. Brazier, J. A., Onishi I., Sasaki S., Binding of two bis-bipyridine minor groove binders to a DNA template in the presence of Cu2+ ione. Nucleic Acids Symp. Ser., 52, 107-108 (2008).
  45. Taniguchi Y., Togo M., Aoki E., Uchida Y., Sasaki S., Synthesis of p-amino-WNA derivatives to enhance the stability of the anti-parallel triplex, Tetrahedron, 64,7164-7170 (2008).
  46. Haruta Y., Onizuka K., Watanabe K., Kono K., Nohara A., Kubota K., Imoto S., Sasaki S., Stereoselective synthesis of (t)-2-deoxyolivin based on cycloaddition reaction between the homophthalic anhydride and the chiral cyclohexenone derivative, Tetrahedron, 64, 7211-7218 (2008).

  47. Nasr T., Taniguchi Y., Sasaki S., Synthesis of 1’-Phenyl Substituted Nucleoside Analogs, Heterocycles, 73, 2659-2668 (2007).
  48. Nagatsugi F., Ogata Y., Imoto S., Sasaki S., Efficient Synthesis of 6-Substituted Purine Derivatives using Pd-Catalyzed Cross-Coupling Reactions with 2’-Deoxyguanosine O6-Tosylate, Heterocycles, 73, 493-501 (2007).
  49. Nagatsugi F., Nakayama S., Sasaki S., Development of the Novel Drug Releasing System Triggered by Hybridization with Target Sequence, Nucleosides, Nucleotides, and Nucleic Acids, 26, 799-803 (2007).
  50. Nakagawa O., Ono S., Tsujimoto A., Li Z., Sasaki S., Selective Fluorescence Detection of 8-Oxoguanosine with 8-oxoG-clamp, Nucleosides, Nucleotides, and Nucleic Acids, 26, 645-649 (2007).
  51. Imoto S., Ali M. M., Li Y., Sasaki S., Nagatsugi F., Enzymatic Incorporation of 2-Amino-6-Vinylpurine Derivative, NucleicAcidsSymp. Ser., 51, 357-358 (2007).
  52. Onizuka K., Taniguchi Y., Sasaki S., Development of novel thioguanosine analogs with the ability to specifically modify cytidine, Nucleic Acids Symp. Ser., 51, 5-6 (2007).
  53. Aoki E., Taniguchi Y., Sasaki S., Effective strand invasion ODN incorporating a new bicyclic nucleoside analogue (WNA), NucleicAcids Symp. Ser., 51, 255-256 (2007).
  54. Ono S., Li Z., Koga Y., Tsujimoto A., Nakagawa O., Sasaki S., Development of a Specific Fluorescent Probe for 8-Oxoguanosine, Nucleic Acids Symp. Ser., 51, 315-316 (2007).
  55. Taniguchi Y., Kool E. T., Syntheses and properties of low-polarity shape mimics of 8oxopurines, Nucleic Acids Symp. Ser., 51, 217-218 (2007).
  56. Taniguchi Y., Kool E. T., Nonpolar Isosteres of Damaged DNA Bases: Effective Mimicry of Mutagenic Properties of 8-Oxopurines, J. Am. Chem. Soc., 129, 8836-8844 (2007).
  57. Uzu T., Sasaki S., A New Copper(II) Complex as an Efficient Catalyst of Luminol Chemiluminescence, Organic Lett., 9, 4383-4386 (2007).
  58. Alam Md., Majumdar A., Thazhathveetil A., Liu S.-T., Liu J.-Lan., Puri N., Cuenoud B., Sasaki S., Miller P., Seidman M., Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo, Biochemistry, 46, 10222-10233 (2007).
  59. Nakagawa O., Ono S., Li Z., Tsujimoto A., Sasaki S., Specific Fluorescent Probe for 8-Oxoguanosine, Angew. Chem. Int. Ed., 46, 4500-4503 (2007).
  60. Tsujita S., Tanada M., Kataoka T.,Sasaki S., Equilibrium shift by target DNA substrates for determination of DNA binding ligands, Bioorg. Med. Chem. Lett., 17, 68-72 (2007).

  61. Nakayama S., Nagatsugi F., Sasaki S., Novel drug releasing system triggered by hybridization with target sequence, NucleicAcidsSymp. Ser., 50, 143-144 (2006).
  62. Kataoka T., Tanada M., Onishi I., Sasaki S., Recognition of DNA with assembly of minor groove binders mediated by metal complexation, Nucleic Acids Symp. Ser., 50, 161-162 (2006).
  63. Aoki E., Taniguchi Y., Togo M., Sasaki S., Effects of the modified aromatic ring of WNA on stability of triplex DNA, NucleicAcidsSymp. Ser., 50, 185-186 (2006).
  64. Nakagawa O., Ono S., Tsujimoto A., Li Z., Sasaki S., Fluorescence detection of 8-oxoguanosine by G-clamp derivatives, NucleicAcids Symp. Ser., 50, 21-22 (2006).
  65. Sasaki S., Nagatsugi F., Application of unnatural oligonucleotides to chemical modification of gene expression, Current Opin.Chem. Biol., 10, 615-621 (2006).
  66. Tanada M., Tsujita S., Kataoka T., Sasaki S., Cu2+-Mediated Assembly of the Minor Groove Binders on the DNA Template with Sequence Selectivity, Organic Lett., 8, 2475-2478 (2006).
  67. Ali M. M., Oishi M., Nagatsugi F., Mori K., Nagasaki Y., Kataoka K., Sasaki S., Intracellular Ability of an Inducible Alkylation System to Exhibit Antisense Effects with Greater Potency and Selectivity, Angew. Chem. Int. Ed., 45, 3136-3140 (2006).
  68. Taniguchi Y., Nakamura A., Senko Y., Nagatsugi F., Sasaki S., Effects of Halogenated WNA Derivatives on Sequence Dependency for Expansion of Recognition Sequences in the Non-Natural Type Triplexes, J. Org. Chem., 71, 2115-2122 (2006).
  69. Ali M. M., Nagatsugi F., Sasaki S., Nakahara R., Maeda M., Application of 2-Amino-6-Vinylpurine as an Efficient Agent for Conjugation of Oligonucleotides, Nucleosides, Nucleotides, and Nucleic Acids, 25, 159-169 (2006).
  70. Tanada M., Tsujita S., Sasaki S., Design of New Bidentate Ligands Constructed of Two Hoechst 33258 Units for Discrimination of the Length of Two A3T3 Binding Motifs, J. Org. Chem., 71, 125-134 (2006).

  71. Yamada Y., Kogure K., Nakamura Y., Inoue K., Akita H., Nagatsugi F., Sasaki S., Suhara T., Harashima H., Development of efficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure, Biol. Pharm.Bull., 28, 1939-1942 (2005).
  72. Sasaki S., Nagatsugi F., Ali M. M., Mori S., Nakayama S., Molecular Design for DNA Hybridization-Promoted Reactions with High Efficiency and Selectivity, Collection Symposium Series, 7, 115-126 (2005).
  73. Ali M. M., Nagatsugi F., Nakayama S., Alam M. R., Kawasaki T., Sasaki S., Design of highly efficient and selective transfer reaction of nitrosyl group to dC and dMC resulting in specific deamination, Nucleosides, Nucleotides, and Nucleic Acids, 24, 721-724 (2005).
  74. Taniguchi Y., Nakamura A., Senko Y., Kodama K., Nagatsugi F., Sasaki S., Expansion of triplex recognition codes by the use of novel bicyclic nucleoside derivatives (WNA), Nucleosides, Nucleotides, and Nucleic Acids, 24, 823-827 (2005).
  75. Tanada M., Sasaki S., Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groove binders, Nucleic Acids, Symp. Ser., 49, 1-2 (2005).
  76. Taniguchi Y., Nakamura A., Aoki E., Sasaki S., Modification of the aromatic ring of the WNA analogues for expansion of the triplex recognition codes, Nucleic Acids, Symp. Ser., 49, 173-174 (2005).
  77. Nagatsugi F., Mori S., Ali M. M., Ogata Y., Sasaki S., Substituent effects on the in situ activation of the double activated cross-linking reaction, Nucleic Acids, Symp. Ser., 49, 175-176 (2005).
  78. Oishi M., Nagatsugi F., Sasaki S., Nagasaki Y., Kataoka K., Smart Polyion Complex Micelles for Targeted Intracellular Delivery of PEGylated Antisense Oligonucleotide with Acid-Labile Linkage, Chembiochem, 6, 718-725 (2005).
  79. Kawasaki T., Nagatsugi F., Ali, M. M., Maeda M., Sugiyama K., Hori K., Sasaki S., Hybridization-Promoted and Cytidine-Selective Activation for Cross-Linking with the Use of 2-Amino-6-Vinylpurine Derivatives, J. Org. Chem., 70, 14-23 (2005).

  80. Taniguchi Y., Nakamura A., Senko Y., Sasaki S., Effects of 5-substituted pyrimidine nucleoside bases of WNA on stability of triplex DNA, Nucleic Acids, Symp. Ser., 48, 69-70 (2004).
  81. Ali M. M., Nagatsugi F., Oishi M., Nagasaki Y., Kataoka K., Sasaki S., Synthesis and evalutaion of the functional oligonucleotides-PEG conjugates, Nucleic Acids, Symp. Ser., 48, 61-62 (2004).
  82. Nagatsugi F., Nakayama S., Ali M. M., Sasaki S., Selective nitrosyl group transfer reaction to cytidine using oligonucleotides bearing S-nitrosothioguanosine, Nucleic Acids, Symp. Ser., 48, 23-24 (2004).
  83. Imoto S., Haruta Y., Watanabe K., Sasaki S., New DNA Binding Ligands as a Model of Chromomycin A3, Bioorg. Med. Chem.Lett., 14, 4855-4859 (2004).
  84. Ali M. M., Alam M. R., Kawasaki T., Nakayama S., Nagatsugi F., Sasaki S., Sequence- and Base-Specific Delivery of Nitric Oxide to Cytidine and 5-Methylcytidine Leading to Efficient Deamination, J. Am. Chem. Soc., 126, 8864-8865 (2004).
  85. Sasaki S., Kurosaki F., Haradahira T., Yamamoto F., Maeda J., Okauchi T., Suzuki K., Suhara T., Maeda M., Synthesis of 11C-Labeled Bis(phenylalkyl)amine and Their in Vitro and in Vivo Binding Properties in Rodent and Monkey Brains, Biol. Pharm.Bull., 27, 531-537 (2004).
  86. Nagatsugi F., Sasaki S., Chemical Tools for Targeted Mutagenesis of DNA Based on Triple Helix Formation., Biol. Pharm. Bull., 27, 463-467 (2004).
  87. Sasaki S., Taniguchi Y., Takahashi R., Senko Y., Kodama K., Nagatsugi F., Maeda M., Selective Formation of Stable Triplexes Including a TA or a CG Interrupting Site with New Bicyclic Nucleoside Analogues (WNA), J. Am. Chem. Soc., 126, 516-528 (2004).
  88. Tanada M., Shibata Y., Maeda, M., Sasaki S., Bipyrrole derivatives as new DNA-minor groove binders, Heterocycles, 63, 29-39 (2004).

  89. Oishi M., Sasaki S., Nagasaki Y., Kataoka K., pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation, Biomacromolecules, 4, 1426-32 (2003).
  90. Yamamoto F., Kuwano E., Kaneshiro T., Sasaki S., Maeda M., 125I-Labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: synthesis and preliminary tissue distribution., J. Labelled Cpd. Radiopharm., 43, 737-750 (2003).
  91. Tokiwa H., Sera N., Fukuhara K., Utsumi H., Sasaki S., Miyata N., Structural activity relationship between Salmonella-mutagenicity and nitro-orientation of nitroazaphenanthrenes, Chemico-Biological Interactions, 146, 19-25 (2003).
  92. Taniguchi Y., Senko Y., Kodama K., Nakamura A., Sasaki S., Design and evaluation of novel nucleoside analogs (WNA) for specific formation of non-natural type triplexes containing a TA or CG interrupting site., Nucleic Acids Res. Suppl., 3, 113-114 (2003).
  93. Fuchigami T., Haradahira T., Arai T., Okauchi T., Maeda J., Suzuki K., Yamamoto F., Suhara T., Sasaki S., Maeda M., Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: An N-methyl-D-aspartate (NMDA) receptor antagonist, Biolog. Pharm. Bull., 26, 1570-1573 (2003).
  94. Nagatsugi F., Suenaga Y., Sasaki S., Efficient cross-linking reactions by functional nucleobases capable of in situ activation under neutral conditions, Nucleic Acids Res. Suppl., 3, 155-156 (2003).
  95. Kundu M., Nagatsugi F., Majumdar A., Miller P. S., Seidman M. M., Enhancement and inhibition by 2'-O-hydroxyethyl residues of gene targeting mediated by triple helix forming oligonucleotides., Nucleosides Nucleotides Nucleic Acids, 22, 1927-38 (2003).
  96. Nagatsugi F., Sasaki S., Miller P. S., Seidman M. M., Site-Specific Mutagenesis by Triple-Helix Forming Oligonucleotides Containing a Reactive Nucleoside Analogue, Nucleic Acids Res., 31, e31 (2003).

  97. Nagatsugi F., Matsuyama Y., Maeda M., Sasaki S., Selective cross-linking to the adenine of the TA interrupting site within the triple helix, Bioorg. Med. Chem. Lett., 12, 487-9 (2002).
  98. Nagatsugi F., Sasaki S., Miller P. S. and Seidman M.M. A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions. Nucleic Acids Res. Suppl., 2, 31-32 (2002).
  99. Ali M. M, Nagatsugi F., Yamamoto F., Maeda M., Sasaki S., 2-Amino-6-Vinylpurine as a Tool of Post Synthetic Conjugation of Oligonucleotides with Radio-, Spin-, Fluorescence Label and Peptides, Nucleic Acids Res. Suppl. , 2, 149-150(2002).
  100. Yosuke Taniguchi, Ryo Takahashi, Keiichi Kodama, Yusuke Senko, Minoru Maeda and Shigeki Sasaki, Selective formation of non-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA) analogs, Nucleic Acids Res. Suppl. , 2, 34-35 (2002).

  101. F. Nagatsugi, D.Usui, T. Kawasaki, M. Maeda, S. Sasaki, Selective Reaction to a Flipping Cytidine of the Duplex DNA Mediated by Triple Helix Formation, Bioorg. Med. Chem. Lett, 11, 343-345 (2001).
  102. Fumi Nagatsugi, Natsuko Tokuda, MinoruMaeda and Shigeki Sasaki, A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions, Bioorg. Med. Chem. Lett., 11, 2577-2579 (2001).
  103. Shigeki Sasaki, Hiroyuki Yamauchi, Fumi Nagatsugi, Ryo Takahashi, Yosuke Taniguchi and Minoru Maeda, W-shape nucleic acid (WNA) for selective formation of non-natural anti-parallel triplex including a TA interrupting site, Tetrahedron Lett., 42 6915-6918 (2001).
  104. F. Nagatsugi, T. Kawasaki, N. Tokuda, M. Maeda, S. Sasaki, Site-Directed Alkylation to cytidine within Duplex by the Oligonucleotides Containing Functional Nucleobases, Nucleoside, Nucleotides & Nucleic Acids, 20, 915-919 (2001).
  105. Sasaki, Shigeki; Shibata, Takayuki; Torigoe, Hidetaka; Shibata, Yoshihiro; Minoru, Maeda, Novel Class of DNA Binding Motifs Based on Bistetrahydrofuran and Bisfuran Skeleton with Long Alkyl Chains, Nucleoside, Nucleotides and Nucleic Acids, 20, 551-558 (2001).
  106. Fumi Nagatsugi, Natsuko Tokuda, Minoru Maeda and Shigeki Sasaki, Efficient cross-linking to cytidine under neutral conditions using the 2-amino-6-vinylpurine derivative having an additional activating group, Nucleic Acids Res. Suppl. 1, 87-88 (2001).
  107. Sasaki, Shigeki; Ehara, Takeru; Sakata, Ikuhiro; Fujino, Yasuhiro; Harada, Naozumi; Kimura, Junko; Nakamura, Hideo; Maeda Minoru, Development of Novel Telomerase Inhibitors Based on a Bisndole Unit, Bioorg. Med. Chem. Lett., 11, 583-585 (2001).
  108. S,Sasaki, H. Yamauchi, R. Takahashi, Y. Taniguchi M. Maeda, New base analogs for the formation of non-natural triplexes, Nucleic Acids Res. Suppl. 1, 23-24 (2001).
  109. S,Sasaki, Active Oligonucleotides Incorporating Alkylating Agent as Potential Sequence- and Base Selective Modifier of Gene Expression, Eur. J. Phar. Sci. 13, 43-51 (2001).
  110. Sasaki S., Kanda T., Ishibashi N., Yamamoto F., Haradahira T., Okauchi T., Maeda J., Suzuki K., Maeda M., 4,5,9,10- Tetrahydro-1,4-Ethanobenz[b]quinolizine as a Prodrug for Its Quninolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors, Bioorg. Med. Chem. Lett., 11, 519-521(2001).
  111. Haradahira T., Zhang M., Maeda J.,Okauchi T., Kida T., Kawabe K., Sasaki S., Suhara T., Suzuki K., A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeled analog, Chem. Pharm. Bull., 49, 147-150 (2001).
  112. Sasaki S., Ehara T., Alam M. R., Fujino Y., Harada N., Kimura J., Nakamura H., Maeda M., Solid-Phase Synthesis of a Library Constructed of Aromatic Phosphate, Long Alkyl Chains and Tryptophane Components, and Identification of Potent Dipeptide Telomerase Inhibitors, Bioorg. Med. Chem. Lett. 11, 2581-2584(2001).
  113. 黒崎文枝、佐々木茂貴、原田平輝志、前田純、岡内隆、張明栄、川辺光一、須原哲也、前田稔、11C標識NMDA/NR2Bサブユニット選択的なPETリガンドの合成とインビトロ・インビボ脳内分布、核医学38,596 (2001).

  114. Alam M. R., Maeda M., Sasaki S., DNA-Binding Peptides Searched from the Solid-Phase Combinatorial Library with the Use of the Magnetic Beads Attaching the Target Duplex DNA, Bioorg. Med. Chem., 8, 465-473 (2000).
  115. Ishibashi N., Kuwamura T., Sano H., Yamamoto F., Haradahira T., Suzuki K., Suhara T., Sasaki S., Maeda M., Synthesis and Evaluation of New 18F- and 11C-Labelled 6,11-Ethanobenzo[b]quinolizinium Derivatives for Imaging of the NMDA Receptor at the TCP-Binding Site, J. Labelled. Cpd. Radiopharm., 43, 375-383(2000).

  116. Nagatsugi, F., Kawasaki T., Usui D., Maeda M., Sasaki S., Highly Efficient and Selective Cross-Linking to Cytidine Based on the New Strategy for Auto-Activation within Duplex , J. Am. Chem. Soc., 121, 6753-6754 (1999).
  117. Matsuura N., Yashiki Y., Nakashima S., Maeda M., Sasaki S., Shortcut Stereoselective Synthesis of 1-b-Alkyl-2-Deoxyribose Derivatives via Wittig-Horner-Emons Reaction, Heterocycles, 51, 975-978 (1999).
  118. Sasaki S., Nagatsugi F., Maeda M., 2-Deoxy Nucleoside Derivatives off 6-Substituted 2-Aminopurine as Highly Efficient and Selective Cross-Linking Agent to Cytidine, Coll. Czech. Chem. Commun., Symp. Series, 2, 114-118 (1999).
  119. Shibata T., Torigoe H., Shibata Y., Maeda M., Sasaki S., Novel DNA-Binding Ligands with Sequence Selectivity Based on Hydrophobic Structure, Nucleic Acids., Symp. Ser., 42, 251-252 (1999).
  120. Kawasaki T., Nagatsugi F., Usui D., Maeda M., Sasaki S., Efficient cross-linking to cytidine by functional nucleobases capable of in situ activation, Nucleic Acids., Symp. Ser., 42, 43-44 (1999).
  121. Alam M. R., Maeda M., Sasaki S., DNA Binding Affinity of Pentapeptides Selected from Combinatorial Library, Nucleic Acids.,Symp. Ser., 42, 173-174 (1999).
  122. Sakata K., Hamase K., Sasaki S., Maeda M., Zaitsu K., Reversible Fluorescence Derivatization of Amino Groups Using Dansylaminomethylmaleic Acid via Its Anhydride, Anal. Sci., 15, 1095-1099 (1999).

  123. Sasaki S., Maruta K., Naito H., Maemura R., Kawahara E., Maeda M., In Vitro Antitumor Activities of New Synthetic Bistetrahydrofuran Derivatiaves as Analogs of Annonaceous Acetogenins, Chem. Pham. Bull., 46, 154-158 (1998).
  124. Sasaki S., Maruta K., Naito H., Maemura R., Kawahara E., Maeda M., Novel Acyclic Ligands for Metal Cations Based on the Adjacent Bistetrahydrofuran as Analogs of Natural ANNONACEOUS Acetogenins, Tetrahedron, 54, 2401-2410 (1998).
  125. 松井晶子、高橋司、松尾浩民、佐々木茂貴、前田稔、澤田康文、アミオダロンをはじめとする抗不整脈薬などによる薬剤性パーキンソニズムの基礎的研究、Progress in Medicine, Vol. 18, suppl. 1, 612-616 (1998).
  126. Matsui A., Matsuo H., Takanaga H., Sasaki S., Maeda M., Sawada Y., Prediction of Catalepsies Induced by Amiodarone, Aprindine and Procaine-Similarity in Conformation of Diethylaminoethyl Side Chain, J. Pharmacol. Experimental Therapeutics, 287, 725-732 (1998).
  127. Sasaki S., Hashimoto T., Obana N., Yasuda H., Uehara, Y., Maeda M., Design of New Inhibitors for CDC2 Kinase Based on a Multiple Pseudosubstrate Structure, Bioorg. Med. Chem. Lett., 8, 1019-1022 (1998).
  128. Nagatsugi F., Kawasaki T., Tanaka Y., Maeda M., Sasaki S., Structural analysis of cross-linked addeucts with the oligonucleotides incorporating 2-amino-6-vinylpurine Nucleic Acids, Symp. Ser., 39, 103-104 (1998).
  129. Alam, M. R., Tanaka Y., Maeda M., Sasaki S., Random search of new peptide ligands towards duplex DNA by the application of combinatorial technology, Nucleic Acids, Symp. Ser., 39, 69-70 (1998).
  130. Sasaki, S., Ishibashi N., Kuwamura T., Sano H., Matoba M., Nisikawa, T., Maeda M., Excellent Acceleration of the Diels-Alder Reaction by Microwave Irradiation for the Synthesis of New Fluorine-Substituted Ligands of NMDA Receptor, Bioorg. Med.Chem. Lett., 8, 2983-2986 (1998).
  131. Haradahira T. Sasaki S. Maeda M. Kobayashi K. Inoue O. Tomita U. Nishikawa T. Suzuki K.; Synthesis and Brain Distribution of Carbon-11 Labeled Analogs of Antagonists for the NMDA Receeptor Coupled PCP-Binding Site. J. Labelled. Cpd. Radiopharm., 41, 843-858 (1998).

  132. Nagatsugi F., Uemura K., Nakashima S., Maeda M., Sasaki S., 2-Aminopurine Derivatives with C6-Substituted Olefin as Novel Cross-Linking Agents and the Synthesis of the Corresponding b-Phosphoramidite Precursors, Tetrahedron, 53, 3035-3044 (1997).
  133. Nakashima S., Matsuura N., Nagatsugi F., Maeda M., Sasaki S., Synthesis and Evaluation of Oligonucleotides Incorporating Novel Artificial Nucleobases for the Selective Formation of Non-Natural Type Triplexes, Nucleic Acids, Symp. Ser., 37, 33-34 (1997).
  134. Nagatsugi F., Kawasaki T., Maeda M., Sasaki S., Novel Cross-Linking Reaction of Oligonuceotides Incorporating New Base Analogs with Selective Reactivity towad Cytidine, Nucleic Acids, Symp. Ser., 37, 67-68 (1997).
  135. Nagatsugi F., Uemura K., Nakashima S., Maeda M., Sasaki S., 2-Aminopurine Derivatives with C6-Substituted Olefin as Novel Cross-Linking Agents and the Synthesis of the Corresponding b-Phosphoramidite Precursors, Tetrahedron, 53, 3035-3044 (1997).
  136. Nakashima S., Matsuura N., Nagatsugi F., Maeda M., Sasaki S., Synthesis and Evaluation of Oligonucleotides Incorporating Novel Artificial Nucleobases for the Selective Formation of Non-Natural Type Triplexes, Nucleic Acids, Symp. Ser., 37, 33-34 (1997).
  137. Nagatsugi F., Kawasaki T., Maeda M., Sasaki S., Novel Cross-Linking Reaction of Oligonuceotides Incorporating New Base Analogs with Selective Reactivity towad Cytidine, Nucleic Acids, Symp. Ser., 37, 67-68 (1997).


総説・著書
  1. 中川治、佐々木茂貴 「核酸をトリガーとする増幅反応」、化学、化学同人、60、70-71(2005)
  2. 谷口陽祐、佐々木茂貴 「3本鎖DNA認識コード拡張のための人工ヌクレオシドの開発」、有機合成化学協会誌、62、1026-1037(2004)
  3. 佐々木茂貴 「ゲノムケミストリー」(関根光雄、齋藤烈 編)、第2章ゲノムに機能する人工核酸、2.6ゲノムクロスリンク能をもつ人工核酸、講談社、東京、89-100(2003)
  4. 佐々木茂貴 「インテリジェント材料・技術の最新開発動向、インテリジェント機能性核酸の創製」、シーエムシー出版(2003)
  5. 佐々木茂貴、永次史 「遺伝子発現機構を標的とする核酸医薬品の新しい化学」、ファルマシア(2003)
  6. 佐々木茂貴 「ゲノム標的化学遺伝子に働くロボットを目指して」、日本化学会生体機能関連化学部会ニュースレター、17、101-104(2003)
  7. 佐々木茂貴 「放射薬品化学」、第5章標識化合物の合成、廣川書店、東京(1999)
  8. 佐々木茂貴 「3本鎖DNA形成による遺伝子発現の化学的制御(アンチジーン法)のための分子設計」、有機合成化学協会誌、55、590-599(1997)
  9. 佐々木茂貴 「コンビナトリアルケミストリー」、蛋白質表面認識分子探索のためのコンビナトリアルテクノロジーの応用−水溶液中での小さなペプチド同士の強い相互作用の検索−、化学同人、京都、99-101(1997)