Graduate School of Pharmaceutical Sciences, Kyushu University
Bioorganic and Synthetic Chemistry

 Publication List (2017-1997)

  1. Wang L., Taniguchi Y.*, Okamura H. and Sasaki S.*, Effect of the 3-halosubstitution of the 2'-deoxy aminopyridinyl-pseudocytidine derivatives on the selectivity and stability of antiparallel triplex DNA with a CG inversion site,Bioorg. Med.Chem.,accepted DOI: 10.1016/j.bmc.2017.05.035  
  2. Taniguchi Y.*, Development of damaged nucleoside mimics for inhibition of their repair enzymes,YAKUGAKU ZASSHI137(3), 293-300 (2017) DOI:  
  3. Kawara K., Tsuji G., Taniguchi Y., Sasaki S.*, Synchronized Chiral Induction Between [5] Helicene-Spermine Ligand and B-Z DNA transition,Chemistry - A European Journal.23(8), 1763-1769 (2017)Doi: 10.1002/chem.201605276.

         Chem. Eur. J.

  4. Okamura H,, Taniguchi Y.*, Sasaki S.*, Aminopyridinyl-pseudodeoxycytidine derivatives selectively stabilize antiparalleltriplex DNA with multiple CG inversion sites.Angew. Chem. Int. Ed.128(40), 12633-12637 (2016)DOI: 10.1002/ange.201606136
  5. Fuchi Y., Fukuda T., Sasaki S.*, Synthetic Receptor Molecules for Selective Fluorescent Detection of 8-oxo-dGTP inAqueous Media,Org. Biomol. Chem.14, 7949-7955 (2016)doi: 10.1039/C6OB01485B 
  6. Yin Y., Sasaki S., Taniguchi Y.*, Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNApolymerase and cell proliferation,Bioorg. Med. Chem. 24(16), 3856-3861 (2016)doi: 10.1016/j.bmc.2016.06.030 
  7. Nishioka T., Oshiro I., Onizuka K., Taniguchi Y. and Sasaki S.*, Efficient thymidine-selective DNA interstrand photo-activecrosslinking by the 6-thioguanine connected via an ethylene-linker to the 2'-deoxyribose unit,Chem. Pharm. Bull.64(9),1315-1320 (2016)
  8. Koga Y., Taniguchi Y*, Kikukawa Y, Sasaki S*, Recognition and detection of 8-oxo-rG in RNA using the DNA/OMeRNAchimera probes containing fluorescent adenosine-diazaphenoxazine analogue,Bioorg. Med. Chem. 24(6), 1308-1313(2016)doi: 10.1016/j.bmc.2016.02.001
  9. Abe S. Y., Sasaki S*, DNA cleavage at the AP site viab-elimination mediated by the AP sitebindingligands,Bioorg. Med.Chem. 24(4) 910-914 (2016)  doi: 10.1016/j.bmc.2016.01.016
  10. Yin Y., Sasaki S., Taniguchi Y.*, Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Actibities,ChemBioChem, 17(7) 566-569 (2016)doi/10.1002/cbic.201500589.  

              Org. Biomol. Chem                             Angew Chem Int. Ed.
                          Bioorg. Med. Chem.                                                Chem. Pharm. Bull.
                       ChemBioChem                        Bioorg. Med. Chem.     Bioorg. Med. Chem.

  11. Fuchi Y, Sasaki S*, New NitroG-Grasp Molecules with Enhanced Capture Reactivity for 8-Nitroguanosine in the AqueousMedia,Chem. Pharm. Bull.63 (11) 913-919. (2015)
  12. Taniguchi Y*, Tomizaki A, Matsueda N, Okamura H, Sasaki S*, Enhancement of TFO Triplex Formation by Conjugation withPyrene via Click Chemistry,Chem. Pharm. Bull.63 (11) 920-926. (2015)
  13. Koda H., Brazier J., Onishi I., Sasaki S*, Strong Positive Cooperativity in Binding to the A3T3 Repeat by Hoechst 33258Derivatives Attaching the Quinoline Units at the end of a Branched Linker,Bioorg. Med. Chem.23(15), 4583-4590 (2015)doi:10.1016/j.bmc.2015.05.056
  14. Kikuta K. Haishun P. Brazier J. Taniguchi Y. Onizuka K. Nagatsugi F. Sasaki S*. Stabilization of the i-motif structure by theintrastrand cross-link formation,Bioorg. Med. Chem. Lett.25(16), 3307-3310 (2015)doi:10.1016/j.bmcl.2015.05.064
  15. Oshiro I. Jitsuzaki D. Onizuka K. Nishimoto A. Taniguchi Y. and Sasaki S*. Site-specific modification of the 6-amino group ofadenosine in RNA by an inter-strand functionality-transfer reaction using an S-functionalized-4-thiothymidine,ChemBioChem, 16(8), 1199-1204 (2015)doi: 10.1002/cbic.201500084
  16. Yin Y. Sasaki S. and Taniguchi Y*. Recognition and excision properties of 8-halogenated-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguaanosine analogues and FPG and hOGG1 inhibitors,ChemBioChem, 16(8), 1190-1198 (2015)doi: 10.1002/cbic.201402690
  17. Taniguchi Y*., Kikukawa Y and Sasaki S*. Discrimination Between 8-Oxo-2'-Deoxyguanosine and 2'-Deoxyguanosine in  DNA by the Single Nucleotide Primer Extension Reaction with Adap Triphosphate,Angew. Chem. Int. Ed.54(17), 5147-5151(2015)doi: 10.102/anie.201412086.
  18. Fuchi Y., Obayashi H. and Sasaki S*. Development of New 1,3-Diazaphenoxazine Derivatives (ThioG-Grasp) to CovalentlyCapture 8-Thioguanosine,Molecules.,20(1), 1078-1087 (2015)doi: 10.3390/molecules20011078.

            Chem. Pharm. Bull.
                 Bioorg. Med. Chem. Lett.                   Chem. Pharm. Bull.
                      ChemBioChem                         ChemBioChem                                     Bioorg. Med. Chem.  
                               Molecules                                                     Angew Chem Int. Ed.

  19. Okamura H., Taniguchi Y*. and Sasaki S*. An Isocytidine Derivative with a 2-Amino-6-methylpyridine Unit for SelectiveRecognition of the CG Interrupting Site in an Antiparallel Triplex DNA,ChemBioChem.15(16), 2374-2378 (2014)doi: 10.1002/cbic.201402328,.  
  20. Jitsuzaki D., Onizuka K., Nishimoto A., Oshiro I., Taniguchi Y. and Sasaki S*. Remarkable acceleration of the DNA/RNAinter-strand functionality-transfer reaction to modify a cytosine residue: the proximity effect via complexation with a metalcation,Nucleic Acids Res.,42(13), 8808-8815 (2014)doi: 10.1093/nar/gku538.
  21. Yamada Y. Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S. and Harashima H. Ananocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line,Biomaterials, 35(24), 6430-6438(2014)DOI: 10.1016/j.biomaterials.2014.04.017
  22. Fuchi Y. and Sasaki S.*, Efficient Covalent Capture of 8-Nitroguanosine via a Multiple Hydrogen-Bonded.Org. Lett., 16(6),1760-1763 (2014)doi:10.1021/ol500452r
  23. Goto T., Shiina A., Murata T., Tomii M., YamazakiT., Yoshida K., Yoshino T., Suzuki O., Sogawa Y., Mizukami K., TakagiN.,Yoshitomi T., Etori M., Tsuchida H., Mikkaichi T., Nakao N., Takahashi M., Takahashi H, Sasaki S. Identification of the5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highlyselective PDE4B inhibitorsBioorg. Med. Chem.Lett., 24(3), 893-899 (2014)DOi: 10.1016/j.bmcl.2013.12.076
  24. Yizhen Y., Taniguchi Y.* and Sasaki S.*, Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its base pairing properties.Tetrahedron, 70(11), 2040-2047 (2014)doi: 10.1016/j.tet.2014.01.047.
  25. Taniguchi Y.*, Fukabori K., Kikukawa Y., Koga Y and Sasaki S.*,2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dG in DNA.  Bioorg. Med. Chem. 22(5), 1634-1641 (2014)DOI:
  26. Taniguchi Y., Koga Y., Shigeki Sasaki*. Synthesis of 8-oxoguanosine phosphoramidite and its incorporation intooligoribonucleotides.Current Protocols in Nucleic Acid Chemistry, UNIT4.58 56:4.58.1-4.58.10DOI:10.1002/0471142700.nc0458s56

                               Org. Lett.                                                              Nucleic Acids Res.
                         Bioorg. Med. Chem.                                                                  Tetrahedron

  27. Sasaki H. and Sasaki S*. B-Z Transition of (dA-T)n Duplex Induced by Spermine Porphyrin-Conjugate via anIntermediateDNA Conformation.Chem. Comm.,49(79) 9024-9026(2013)  DOI: 10.1039/C3CC45213A 
  28. Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N.,Takahashi M., Hasegawa M. and Sasaki S. Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidinederivativesas novel and potent PDE4 inhibitors.Bioorg. Med. Chem.  21 (22) 7025-7037 (2013).DOI:
  29. Tsuji G,, Kawakami K and Sasaki S*. Enantioselective Binding of Chiral 1,14-Dimethyl[5]Helicene-spermine Ligands with B-and Z-DNA.Bioorg. Med. Chem.  21 (19) 6063-6068 (2013).DOI:
  30. Okamura H, Taniguchi Y* and Sasaki S*.N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits a selective recognition ofa CG interrupting site for the formation of anti-parallel triplexes,Org. Biomol. Chem., 11. 3918-3924 (2013)DOI: 10.1039/C3OB40472B
  31. Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N.,TakahashiM., Hasegawa M. and Sasaki S. Identification of the fused bicyclic4-amino-2-phenylpyrimidine derivatives as noveland potent PDE4 inhibitors.Bioorg. Med. Chem. Lett., 23(11), 3325-3328 (2013)DOI:
  32. Nishimoto A., Jitsuzaki D., Onizuka K., Taniguchi Y., Nagatsugi F. and Sasaki S*. 4-Vinyl-Substituted PyrimidineNucleosides Exhibit the Efficient and SelectiveFormation of Interstrand Cross-Links with RNA and duplex DNA,NucleicAcids Res.,41(13) 6774-6781 (2013)DOI: 10.1093/nar/gkt197 
  33. Koga Y., Taniguchi Y and Sasaki S*. Synthesis of the Oligoribonucleotides Incorporating 8-Oxo-guanosine and Evaluation oftheir Base Pairing Properties,  Nucleosides, Nucleotides and Nucleic Acids, 32(3), 124-136. (2013)DOI: 10.1080/15257770.2013.767461
  34. Taniguchi Y., Okamura H., Fujino N., Sasaki S*. Synthesis of 1'-phenyl-2-OMe ribose analogues connecting the thyminebase at the 1' position through a flexible linker for the formation of a stable anti-parallele triplex DNA,Tetrahedron, 69(2), 600-606 (2013)DOI: 10.1016/j.tet.2012.11.016 

                                 Chem. Comm.    
                           Org. Biomol. Chem                                                               Bioorg. Med. Chem.
                                        Nucleic Acids Res.                                           Nucleosides, Nucleotides and Nucleic Acids

  35. Nasr T, Taniguchi Y., Takaki T., Okamura H., Sasaki S*. Properties of Oligonucleotidewith Phenyl-Substituted CarbocyclicNucleoside Analogues for the Formation ofDuplex and Triplex DNA,Nucleosides, Nucleotides and Nucleic Acids,31(12),8441-860. (2012)DOI: 10.1080/15257770.2012.737970.
  36. Taniguchi Y* and Sasaki S*., An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin genewith triplex forming oligonucleotides containing a W-shaped nucleoside analogue (WNA-bT),Org. Biomol. Chem., 10(41),8336-8341. (2012)DOI: 10.1039/c2ob26431e
  37. Aoki E., Taniguchi Y., Wada Y., Sasaki S*, Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-bT) containing an ortho-methyl-substituted phenyl ring,ChemBioChem,. 13(8), 1152-1160 (2012)DOI: 10.1002/cbic.201200066
  38. Abe Y., Nakagawa O., Yamaguchi R., Sasaki S.*, Synthesis and binding properties of new selective ligands for thenucleobase opposite the AP site,Bioorg. Med. Chem. 20(11), 3470-3479 (2012).DOI: 10.1016/j.bmc.2012.04.009.
  39. Onizuka K., Nishioka T., Li Z., Jitsuzaki D., Taniguchi Y. and Sasaki S.*, Aneficient and simple method for site-selectivemodification of O6-methyl-2'-deoxyguanosine in DNA,,Chem. Comm.,48 (33), 3969-3971.DOI: 10.1039/c2cc17621a
  40. Sasaki S.*, Onizuka K., Taniguchi Y., Oligonucleotide containing S-Functionalized 2'-deoxy-6-thioguanosine: Facile Toolsfor Base-Selective and Site Specific Internal Modification of RNA,Current Protocols in Nucleic Acid Chemistry, 4.49.1-4.49.16 (2012)DOI: 10.1002/0471142700.nc0449s.48
  41. Taniguchi Y, Koga Y, Fukabori K, Kawaguchi R, Sasaki S.*, OFF-to-ON type fluorescent probe for the detection of 8-oxo-dGin DNA by the Adap-masked ODN probe,Bioorg. Med. Chem. Lett., 22(1), 543-546 (2012)DOI: 10.1016/j.bmcl.2011.10.093.

                      Org. Biomol. Chem                                          Nucleosides, Nucleotides and Nucleic Acids
                            Chem. Comm.                      ChemBioChem                        Bioorg. Med. Chem.
                     Bioorg. Med. Chem. Lett.                                          

  42. Sasaki S., Onizuka K. and Taniguchi Y, The oligodeoxynucleotide probes for the site-specific modification of RNA,Chem.Soc. Rev.,40(12), 5698-5706 (2011)DOI: 10.1039/c1cs15066a.
  43. Taniguchi Y, Kawaguchi R, Sasaki S., Adenosine-1,3-diazaphenoxazine Derivative for Selective Base Pair Formation with 8-Oxo-2'-deoxyguanosine in DNA,J. Am. Chem. Soc., 133, 7272-7275 (2011).DOI: 10.1021/ja200327u.  
  44. Koga Y, Fuchi Y, Nakagawa O, Sasaki S., Optimization of Fluorescence Property of the 8-OxodGclamp Derivative for BetterSelectivity for 8-Oxo-2'-deoxyguanosine,Tetrahedron, 67, 6746-6752 (2011).DOI: 10.1016/j/.tet.2011.03.111,
  45. Onizuka K, Shibata A, Taniguchi Y, Sasaki S., Pin-Point Chemical Modification of RNA with DiverseMolecules through theFunctionality Transfer Reaction and Copper-CatalyzedAzide-Alkyne Cycloaddition Reaction,Chem. Comm.,47(17), 5004-5006 (2011).DOI: 10.10389/C1CC10582E,

                   Chem. Soc. Rev.

              J. Am. Chem. Soc                                    Tetrahedron                   Chem. Comm.

  46. Taniguchi Y., Nitta A., Park S. M., Kohara A., Uzu T., Sasaki S., The ODN probes conjugating the Cu(II) complex enhancethe luminol chemiluminescense by assembling on the DNA template,Bioorg. Med. Chem.18, 8614-8617 (2010).
  47. Doi I., Tsuji G., Kawakami K., Nakagawa O., Taniguchi Y., Sasaki S., The Spermine-Bisaryl Conjugate as a Potent Inducerfor the B to Z-DNA Transition,Chem. Eur. J.16, 11993-11999 (2010).  
  48. Imoto S., Hori T., Hagihara, S., Taniguchi Y., Sasaki S., Nagatsugi F., Alteration of Cross-linking Selectivity with the 2'-OMeAnalogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense EffectBioorg. Med. Chem. Lett., 20, 6121-6124 (2010).
  49. Onizuka K., Taniguchi Y., Sasaki S., Activation and Alteration of Base Selectivity by Metal Cations in the Functionality-Transfer Reaction for RNA Modification,Bioconjugate Chem.21, 1508-1512 (2010).
  50. Nagatsugi F., Sasaki S., Synthesis of Reactive Oligonucleotides foe Gene Targeting and Their Application to GeneExpression Regulation,Bull. Chem. Soc. Jpn., 83, 744-755 (2010)
  51. Li Z, Nakagawa O, Koga Y, Taniguchi Y., Sasaki S., Synthesis of New Derivatives of 8-oxoG-Clamp for Better Understandingthe Recognition Mode and Improvement of Selective AffinityBioorg. Med. Chem.18, 3992-3998 (2010).
  52. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S.,  The Alkyl-Connected 2-Amino-6-Vinylpurine (AVP)Crosslinking Agent for Improved Selectivity to the Cytosine,Bioorg. Med. Chem.,18. 2894-2901 (2010).
  53. Onizuka K, Taniguchi Y., Sasaki S., A New Usage of Functionalized Oligodeoxynucleotide Probe for Site-SpecificModification of a Guanine Base within RNA,Nucleic Acids Res.38, 1760-1766 (2010).  

  54. Taniguchi Y., Uchida Y., Takaki T., Aoki E., Sasaki S., Recognition of CG interrupting site by W-shaped nucleoside analogs(WNA) having the pyrazole ring in an anti-parallel triplex DNA,Bioorg. Med. Chem.17, 6803-6810 (2009).  
  55. Onizuka K.,Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification of RNA by functionality-transfer ODNprobes,NucleicAcids Symp. Ser.,53, 67-68 (2009).  
  56. Taniguchi Y., Kurose Y., Nishioka T., Nagatsugi F., Sasaki S., Evaluation of theantisense effect ofPEGylatedoligodeoxynucleotidescontaining intelligent nucleoside analogues,Nucleic Acids Symp. Ser., 53,167-168 (2009).  
  57. Onizuka K, Taniguchi Y., Sasaki S., A New Odorless Procedure for the synthesis of 2'deoxy-6-thioguanosine and ItIncorporation Into Oligonucleotides,Nucleosides, Nucleotides, and Nucleic Acids, 28, 752-760 (2009).  
  58. Onizuka K, Taniguchi Y., Sasaki S., Site-specific covalent modification of nucleic acids guided by functionality-transferoligodeoxynucleotidesBioconjugate Chem.20, 799-803 (2009).
  59. Ali M. M., Imoto S., Li Y., Sasaki S. Nagatsugi F., Incorporation of inducible nucleotide analog into DNA by DNApolymerases,Bioorg. Med. Chem.17, 2859-2863 (2009).
  60. Nasr T., Li Z., Nakagawa O., Taniguchi Y., Ono S., Sasaki S., Selective Fluorescence Quenching of the 8-OxoG-clamp by 8-Oxodeoxyguanosine in ODN,Bioorg. Med. Chem. Lett.,19, 727-730 (2009).

  61. Nagatsugi F., Nakahara R., Inoue K., Sasaki S., Synthesis and Evaluation of the Luciferase-Oligodeoxynucleotide for theSequencse-Selective Detection of Nucleic Acids,Arch. Pharm. Chem. Life Sci.,341, 562-567 (2008).
  62. Onizuka K, Taniguchi Y., Nishioka T., Sasaki S., Site-specific modification by functionality-transfer oligonucleotide with thephoto-inducible reactivity.Nucleic Acids Symp. Ser., 52, 367-368 (2008).
  63. Kurose Y., Taniguchi, Y., Nagatsugi F., Sasaki S., Synthesis of new nucleosides analogue connecting 2-amino-6-vinylpurineto the 2’-deoxyribose skeletonviathe methylene linker.Nucleic Acids Symp., Ser.52, 43-44 (2008).
  64. Uchida Y., Taniguchi Y., Aoki E., Togo M., Sasaki S., Formation of a stable triplex incorporating a CG interrupting site by anew WNA derivative containing 3-aminopyrazole as a nucleobase.Nucleic Acids Symp. Ser., 52, 137-138 (2008).
  65. Brazier, J. A., Onishi I., Sasaki S., Binding of two bis-bipyridine minor groove binders to a DNA template in the presence ofCu2+ione.Nucleic Acids Symp. Ser., 52, 107-108 (2008).
  66. Taniguchi Y., Togo M., Aoki E., Uchida Y., Sasaki S., Synthesis of p-amino-WNA derivatives to enhance the stability of theanti-parallel triplex,Tetrahedron,64,7164-7170 (2008).
  67. Haruta Y., Onizuka K., Watanabe K., Kono K., Nohara A., Kubota K., Imoto S., Sasaki S., Stereoselective synthesis of (t)-2-deoxyolivin based on cycloaddition reaction between the homophthalic anhydride and the chiral cyclohexenone derivative,Tetrahedron,64, 7211-7218 (2008).

  68. Nasr T., Taniguchi Y., Sasaki S., Synthesis of 1’-Phenyl Substituted Nucleoside Analogs,Heterocycles,73, 2659-2668 (2007).
  69. Nagatsugi F., Ogata Y., Imoto S., Sasaki S., Efficient Synthesis of 6-Substituted Purine Derivatives using Pd-CatalyzedCross-Coupling Reactions with 2’-Deoxyguanosine O6-Tosylate,Heterocycles,73, 493-501 (2007).
  70. Nagatsugi F., Nakayama S., Sasaki S., Development of the Novel Drug Releasing System Triggered by Hybridization withTarget Sequence,Nucleosides, Nucleotides, and Nucleic Acids,26, 799-803 (2007).
  71. Nakagawa O., Ono S., Tsujimoto A., Li Z., Sasaki S., Selective Fluorescence Detection of 8-Oxoguanosine with 8-oxoG-clamp,Nucleosides, Nucleotides, and Nucleic Acids,26, 645-649 (2007).
  72. Imoto S., Ali M. M., Li Y., Sasaki S., Nagatsugi F., Enzymatic Incorporation of 2-Amino-6-Vinylpurine Derivative,NucleicAcidsSymp. Ser.,51, 357-358 (2007).
  73. Onizuka K., Taniguchi Y., Sasaki S., Development of novel thioguanosine analogs with the ability to specifically modifycytidine,Nucleic Acids Symp. Ser.,51, 5-6 (2007).
  74. Aoki E., Taniguchi Y., Sasaki S., Effective strand invasion ODN incorporating a new bicyclic nucleoside analogue (WNA),Nucleic Acids Symp. Ser.,51, 255-256 (2007).
  75. Ono S., Li Z., Koga Y., Tsujimoto A., Nakagawa O., Sasaki S., Development of a Specific Fluorescent Probe for 8-Oxoguanosine,Nucleic Acids Symp. Ser.,51, 315-316 (2007).
  76. Taniguchi Y., Kool E. T., Syntheses and properties of low-polarity shape mimics of 8oxopurines,Nucleic Acids Symp. Ser.,51, 217-218 (2007).
  77. Taniguchi Y., Kool E. T., Nonpolar Isosteres of Damaged DNA Bases: Effective Mimicry of Mutagenic Properties of 8-Oxopurines,J. Am. Chem. Soc.,129, 8836-8844 (2007).
  78. Uzu T., Sasaki S., A New Copper(II) Complex as an Efficient Catalyst of Luminol Chemiluminescence,Organic Lett.,9, 4383-4386 (2007).
  79. Alam Md., Majumdar A., Thazhathveetil A., Liu S.-T., Liu J.-Lan., Puri N., Cuenoud B., Sasaki S., Miller P., Seidman M.,Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo,Biochemistry,46, 10222-10233 (2007).
  80. Nakagawa O., Ono S., Li Z., Tsujimoto A., Sasaki S., Specific Fluorescent Probe for 8-Oxoguanosine,Angew. Chem. Int.Ed.,46, 4500-4503 (2007).
  81. Tsujita S., Tanada M., Kataoka T.,Sasaki S., Equilibrium shift by target DNA substrates for determination of DNA bindingligands,Bioorg. Med. Chem. Lett.,17, 68-72 (2007).

  82. Nakayama S., Nagatsugi F., Sasaki S., Novel drug releasing system triggered by hybridization with target sequence,NucleicAcids Symp. Ser.,50, 143-144 (2006).
  83. Kataoka T., Tanada M., Onishi I., Sasaki S., Recognition of DNA with assembly of minor groove binders mediated by metalcomplexation,Nucleic Acids Symp. Ser.,50, 161-162 (2006).
  84. Aoki E., Taniguchi Y., Togo M., Sasaki S., Effects of the modified aromatic ring of WNA on stability of triplex DNA,NucleicAcids Symp. Ser.,50, 185-186 (2006).
  85. Nakagawa O., Ono S., Tsujimoto A., Li Z., Sasaki S., Fluorescence detection of 8-oxoguanosine by G-clamp derivatives,Nucleic Acids Symp. Ser.,50, 21-22 (2006).
  86. Sasaki S., Nagatsugi F., Application of unnatural oligonucleotides to chemical modification of gene expression,Current Opin.Chem. Biol.,10, 615-621 (2006).
  87. Tanada M., Tsujita S., Kataoka T., Sasaki S., Cu2+-Mediated Assembly of the Minor Groove Binders on the DNA Templatewith Sequence Selectivity,Organic Lett.,8, 2475-2478 (2006).
  88. Ali M. M., Oishi M., Nagatsugi F., Mori K., Nagasaki Y., Kataoka K., Sasaki S., Intracellular Ability of an InducibleAlkylation System to Exhibit Antisense Effects with Greater Potency and Selectivity,Angew. Chem. Int. Ed.,45, 3136-3140(2006).
  89. Taniguchi Y., Nakamura A., Senko Y., Nagatsugi F., Sasaki S., Effects of Halogenated WNA Derivatives on SequenceDependency for Expansion of Recognition Sequences in the Non-Natural Type Triplexes,J. Org. Chem.,71, 2115-2122(2006).
  90. Ali M. M., Nagatsugi F., Sasaki S., Nakahara R., Maeda M., Application of 2-Amino-6-Vinylpurine as an Efficient Agent forConjugation of Oligonucleotides,Nucleosides, Nucleotides, and Nucleic Acids,25, 159-169 (2006).
  91. Tanada M., Tsujita S., Sasaki S., Design of New Bidentate Ligands Constructed of Two Hoechst 33258 Units forDiscrimination of the Length of Two A3T3 Binding Motifs,J. Org. Chem.,71, 125-134 (2006).

  92. Yamada Y., Kogure K., Nakamura Y., Inoue K., Akita H., Nagatsugi F., Sasaki S., Suhara T., Harashima H., Developmentof efficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure,Biol. Pharm.Bull.,28, 1939-1942 (2005).
  93. Sasaki S., Nagatsugi F., Ali M. M., Mori S., Nakayama S., Molecular Design for DNA Hybridization-Promoted Reactionswith High Efficiency and Selectivity,Collection Symposium Series,7, 115-126 (2005).
  94. Ali M. M., Nagatsugi F., Nakayama S., Alam M. R., Kawasaki T., Sasaki S., Design of highly efficient and selective transferreaction of nitrosyl group to dC and dMC resulting in specific deamination,Nucleosides, Nucleotides, and Nucleic Acids,24,721-724 (2005).
  95. Taniguchi Y., Nakamura A., Senko Y., Kodama K., Nagatsugi F., Sasaki S., Expansion of triplex recognition codes by theuse of novel bicyclic nucleoside derivatives (WNA),Nucleosides, Nucleotides, and Nucleic Acids,24, 823-827 (2005).
  96. Tanada M., Sasaki S., Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groovebinders,Nucleic Acids, Symp. Ser.,49, 1-2 (2005).
  97. Taniguchi Y., Nakamura A., Aoki E., Sasaki S., Modification of the aromatic ring of the WNA analogues for expansion of thetriplex recognition codes,Nucleic Acids, Symp. Ser.,49, 173-174 (2005).
  98. Nagatsugi F., Mori S., Ali M. M., Ogata Y., Sasaki S., Substituent effects on the in situ activation of the double activatedcross-linking reaction,Nucleic Acids, Symp. Ser.,49, 175-176 (2005).
  99. Oishi M., Nagatsugi F., Sasaki S., Nagasaki Y., Kataoka K., Smart Polyion Complex Micelles for Targeted IntracellularDelivery of PEGylated Antisense Oligonucleotide with Acid-Labile Linkage,Chembiochem,6, 718-725 (2005).
  100. Kawasaki T., Nagatsugi F., Ali, M. M., Maeda M., Sugiyama K., Hori K., Sasaki S., Hybridization-Promoted and Cytidine-Selective Activation for Cross-Linking with the Use of 2-Amino-6-Vinylpurine Derivatives,J. Org. Chem.,70, 14-23 (2005).

  101. Taniguchi Y., Nakamura A., Senko Y., Sasaki S., Effects of 5-substituted pyrimidine nucleoside bases of WNA on stability oftriplex DNA,Nucleic Acids, Symp. Ser.,48, 69-70 (2004).
  102. Ali M. M., Nagatsugi F., Oishi M., Nagasaki Y., Kataoka K., Sasaki S., Synthesis and evalutaion of the functionaloligonucleotides-PEG conjugates,Nucleic Acids, Symp. Ser.,48, 61-62 (2004).
  103. Nagatsugi F., Nakayama S., Ali M. M., Sasaki S., Selective nitrosyl group transfer reaction to cytidine usingoligonucleotides bearing S-nitrosothioguanosine,Nucleic Acids, Symp. Ser.,48, 23-24 (2004).
  104. Imoto S., Haruta Y., Watanabe K., Sasaki S., New DNA Binding Ligands as a Model of Chromomycin A3,Bioorg. Med.Chem.Lett.,14, 4855-4859 (2004).
  105. Ali M. M., Alam M. R., Kawasaki T., Nakayama S., Nagatsugi F., Sasaki S., Sequence- and Base-Specific Delivery of NitricOxide to Cytidine and 5-Methylcytidine Leading to Efficient Deamination,J. Am. Chem. Soc.,126, 8864-8865 (2004).
  106. Sasaki S., Kurosaki F., Haradahira T., Yamamoto F., Maeda J., Okauchi T., Suzuki K., Suhara T., Maeda M., Synthesis of11C-Labeled Bis(phenylalkyl)amine and Their in Vitro and in Vivo Binding Properties in Rodent and Monkey Brains,Biol.Pharm.Bull.,27, 531-537 (2004).
  107. Nagatsugi F., Sasaki S., Chemical Tools for Targeted Mutagenesis of DNA Based on Triple Helix Formation.,Biol. Pharm.Bull.,27, 463-467 (2004).
  108. Sasaki S., Taniguchi Y., Takahashi R., Senko Y., Kodama K., Nagatsugi F., Maeda M., Selective Formation of StableTriplexes Including a TA or a CG Interrupting Site with New Bicyclic Nucleoside Analogues (WNA),J. Am. Chem. Soc.,126,516-528 (2004).
  109. Tanada M., Shibata Y., Maeda, M., Sasaki S., Bipyrrole derivatives as new DNA-minor groove binders,Heterocycles,63, 29-39 (2004).

  110. Oishi M., Sasaki S., Nagasaki Y., Kataoka K., pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugatethrough acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation,Biomacromolecules,4,1426-32 (2003).
  111. Yamamoto F., Kuwano E., Kaneshiro T., Sasaki S., Maeda M., 125I-Labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: synthesis and preliminary tissue distribution.,J. Labelled Cpd. Radiopharm.,43,737-750 (2003).
  112. Tokiwa H., Sera N., Fukuhara K., Utsumi H., Sasaki S., Miyata N., Structural activity relationship between Salmonella-mutagenicity and nitro-orientation of nitroazaphenanthrenes,Chemico-Biological Interactions,146, 19-25 (2003).
  113. Taniguchi Y., Senko Y., Kodama K., Nakamura A., Sasaki S., Design and evaluation of novel nucleoside analogs (WNA) forspecific formation of non-natural type triplexes containing a TA or CG interrupting site.,Nucleic Acids Res. Suppl.,3, 113-114 (2003).
  114. Fuchigami T., Haradahira T., Arai T., Okauchi T., Maeda J., Suzuki K., Yamamoto F., Suhara T., Sasaki S., Maeda M.,Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: An N-methyl-D-aspartate (NMDA) receptorantagonist,Biolog. Pharm. Bull.,26, 1570-1573 (2003).
  115. Nagatsugi F., Suenaga Y., Sasaki S., Efficient cross-linking reactions by functional nucleobases capable of in situ activationunder neutral conditions,Nucleic Acids Res. Suppl.,3, 155-156 (2003).
  116. Kundu M., Nagatsugi F., Majumdar A., Miller P. S., Seidman M. M., Enhancement and inhibition by 2'-O-hydroxyethylresidues of gene targeting mediated by triple helix forming oligonucleotides.,Nucleosides Nucleotides Nucleic Acids,22,1927-38 (2003).
  117. Nagatsugi F., Sasaki S., Miller P. S., Seidman M. M., Site-Specific Mutagenesis by Triple-Helix Forming OligonucleotidesContaining a Reactive Nucleoside Analogue,Nucleic Acids Res.,31, e31 (2003).

  118. Nagatsugi F., Matsuyama Y., Maeda M., Sasaki S., Selective cross-linking to the adenine of the TA interrupting site withinthe triple helix,Bioorg. Med. Chem. Lett.,12, 487-9 (2002).
  119. Nagatsugi F., Sasaki S., Miller P. S. and Seidman M.M. A new reactive nucleoside analogue for highly reactive and selectivecross-linking reaction to cytidine under neutral conditions.Nucleic Acids Res. Suppl.,2, 31-32 (2002).
  120. Ali M. M, Nagatsugi F., Yamamoto F., Maeda M., Sasaki S., 2-Amino-6-Vinylpurine as a Tool of Post Synthetic Conjugationof Oligonucleotides with Radio-, Spin-, Fluorescence Label and Peptides,Nucleic Acids Res. Suppl.,2, 149-150(2002).
  121. Yosuke Taniguchi, Ryo Takahashi, Keiichi Kodama, Yusuke Senko, Minoru Maeda and Shigeki Sasaki, Selective formationof non-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA)analogs,Nucleic Acids Res. Suppl.,2, 34-35 (2002).

  122. F. Nagatsugi, D.Usui, T. Kawasaki, M. Maeda, S. Sasaki, Selective Reaction to a Flipping Cytidine of the Duplex DNAMediated by Triple Helix Formation,Bioorg. Med. Chem. Lett,11, 343-345 (2001).
  123. Fumi Nagatsugi, Natsuko Tokuda, MinoruMaeda and Shigeki Sasaki, A new reactive nucleoside analogue for highly reactiveand selective cross-linking reaction to cytidine under neutral conditions,Bioorg. Med. Chem. Lett., 11, 2577-2579 (2001).
  124. Shigeki Sasaki, Hiroyuki Yamauchi, Fumi Nagatsugi, Ryo Takahashi, Yosuke Taniguchi and Minoru Maeda, W-shapenucleic acid (WNA) for selective formation of non-natural anti-parallel triplex including a TA interrupting site,TetrahedronLett.,426915-6918 (2001).
  125. F. Nagatsugi, T. Kawasaki, N. Tokuda, M. Maeda, S. Sasaki, Site-Directed Alkylation to cytidine within Duplex by theOligonucleotides Containing Functional Nucleobases, Nucleoside,Nucleotides & Nucleic Acids, 20, 915-919 (2001).
  126. Sasaki, Shigeki; Shibata, Takayuki; Torigoe, Hidetaka; Shibata, Yoshihiro; Minoru, Maeda, Novel Class of DNA BindingMotifs Based on Bistetrahydrofuran and Bisfuran Skeleton with Long Alkyl Chains,Nucleoside, Nucleotides and NucleicAcids,20, 551-558 (2001).
  127. Fumi Nagatsugi, Natsuko Tokuda, Minoru Maeda and Shigeki Sasaki, Efficient cross-linking to cytidine under neutralconditions using the 2-amino-6-vinylpurine derivative having an additional activating group,Nucleic Acids Res. Suppl.1, 87-88(2001).
  128. Sasaki, Shigeki; Ehara, Takeru; Sakata, Ikuhiro; Fujino, Yasuhiro; Harada, Naozumi; Kimura, Junko; Nakamura, Hideo;Maeda Minoru, Development of Novel Telomerase Inhibitors Based on a Bisndole Unit,Bioorg. Med. Chem. Lett.,11, 583-585 (2001).
  129. S,Sasaki, H. Yamauchi, R. Takahashi, Y. Taniguchi M. Maeda, New base analogs for the formation of non-natural triplexes,Nucleic Acids Res. Suppl.1, 23-24 (2001).
  130. S,Sasaki, Active Oligonucleotides Incorporating Alkylating Agent as Potential Sequence- and Base Selective Modifier ofGene Expression, Eur.J. Phar. Sci.13, 43-51 (2001).
  131. Sasaki S., Kanda T., Ishibashi N., Yamamoto F., Haradahira T., Okauchi T., Maeda J., Suzuki K., Maeda M., 4,5,9,10-Tetrahydro-1,4-Ethanobenz[b]quinolizine as a Prodrug for Its Quninolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors,Bioorg. Med. Chem. Lett.,11, 519-521(2001).
  132. Haradahira T., Zhang M., Maeda J.,Okauchi T., Kida T., Kawabe K., Sasaki S., Suhara T., Suzuki K., A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeledanalog,Chem. Pharm. Bull.,49, 147-150 (2001).
  133. Sasaki S., Ehara T., Alam M. R., Fujino Y., Harada N., Kimura J., Nakamura H., Maeda M., Solid-Phase Synthesis of aLibrary Constructed of Aromatic Phosphate, Long Alkyl Chains and Tryptophane Components, and Identification of PotentDipeptide Telomerase Inhibitors,Bioorg. Med. Chem. Lett.11, 2581-2584(2001).
  134. 黒崎文枝、佐々木茂貴、原田平輝志、前田純、岡内隆、張明栄、川辺光一、須原哲也、前田稔、11C標識NMDA/NR2Bサブユニット選択的なPETリガンドの合成とインビトロ・インビボ脳内分布、核医学38,596 (2001).

  135. Alam M. R., Maeda M., Sasaki S., DNA-Binding Peptides Searched from the Solid-Phase Combinatorial Library with theUse of the Magnetic Beads Attaching the Target Duplex DNA,Bioorg. Med. Chem.,8, 465-473 (2000).
  136. Ishibashi N., Kuwamura T., Sano H., Yamamoto F., Haradahira T., Suzuki K., Suhara T., Sasaki S., Maeda M., Synthesisand Evaluation of New 18F- and 11C-Labelled 6,11-Ethanobenzo[b]quinolizinium Derivatives for Imaging of the NMDAReceptor at the TCP-Binding Site,J. Labelled. Cpd. Radiopharm.,43, 375-383(2000).

  137. Nagatsugi, F., Kawasaki T., Usui D., Maeda M., Sasaki S., Highly Efficient and Selective Cross-Linking to Cytidine Basedon the New Strategy for Auto-Activation within Duplex ,J. Am. Chem. Soc.,121, 6753-6754 (1999).
  138. Matsuura N., Yashiki Y., Nakashima S., Maeda M., Sasaki S., Shortcut Stereoselective Synthesis of 1-b-Alkyl-2-Deoxyribose Derivatives via Wittig-Horner-Emons Reaction,Heterocycles,51, 975-978 (1999).
  139. Sasaki S., Nagatsugi F., Maeda M., 2-Deoxy Nucleoside Derivatives off 6-Substituted 2-Aminopurine as Highly Efficient andSelective Cross-Linking Agent to Cytidine,Coll. Czech. Chem. Commun., Symp. Series,2, 114-118 (1999).
  140. Shibata T., Torigoe H., Shibata Y., Maeda M., Sasaki S., Novel DNA-Binding Ligands with Sequence Selectivity Based onHydrophobic Structure,Nucleic Acids., Symp. Ser.,42, 251-252 (1999).
  141. Kawasaki T., Nagatsugi F., Usui D., Maeda M., Sasaki S., Efficient cross-linking to cytidine by functional nucleobasescapable of in situ activation,Nucleic Acids., Symp. Ser.,42, 43-44 (1999).
  142. Alam M. R., Maeda M., Sasaki S., DNA Binding Affinity of Pentapeptides Selected from Combinatorial Library,NucleicAcids.,Symp. Ser.,42, 173-174 (1999).
  143. Sakata K., Hamase K., Sasaki S., Maeda M., Zaitsu K., Reversible Fluorescence Derivatization of Amino Groups UsingDansylaminomethylmaleic Acid via Its Anhydride,Anal. Sci.,15, 1095-1099 (1999).

  144. Sasaki S., Maruta K., Naito H., Maemura R., Kawahara E., Maeda M., In Vitro Antitumor Activities of New SyntheticBistetrahydrofuran Derivatiaves as Analogs of Annonaceous Acetogenins,Chem. Pham. Bull.,46, 154-158 (1998).
  145. Sasaki S., Maruta K., Naito H., Maemura R., Kawahara E., Maeda M., Novel Acyclic Ligands for Metal Cations Based onthe Adjacent Bistetrahydrofuran as Analogs of NaturalANNONACEOUSAcetogenins,Tetrahedron,54, 2401-2410 (1998).
  146. 松井晶子、高橋司、松尾浩民、佐々木茂貴、前田稔、澤田康文、アミオダロンをはじめとする抗不整脈薬などによる薬剤性パーキンソニズムの基礎的研究、Progress in Medicine, Vol. 18, suppl. 1, 612-616 (1998).
  147. Matsui A., Matsuo H., Takanaga H., Sasaki S., Maeda M., Sawada Y., Prediction of Catalepsies Induced by Amiodarone,Aprindine and Procaine-Similarity in Conformation of Diethylaminoethyl Side Chain,J. Pharmacol. ExperimentalTherapeutics,287, 725-732 (1998).
  148. Sasaki S., Hashimoto T., Obana N., Yasuda H., Uehara, Y., Maeda M., Design of New Inhibitors for CDC2 Kinase Based ona Multiple Pseudosubstrate Structure,Bioorg. Med. Chem. Lett.,8, 1019-1022 (1998).
  149. Nagatsugi F., Kawasaki T., Tanaka Y., Maeda M., Sasaki S., Structural analysis of cross-linked addeucts with theoligonucleotides incorporating 2-amino-6-vinylpurineNucleic Acids, Symp. Ser.,39, 103-104 (1998).
  150. Alam, M. R., Tanaka Y., Maeda M., Sasaki S., Random search of new peptide ligands towards duplex DNA by theapplication of combinatorial technology,Nucleic Acids, Symp. Ser.,39, 69-70 (1998).
  151. Sasaki, S., Ishibashi N., Kuwamura T., Sano H., Matoba M., Nisikawa, T., Maeda M., Excellent Acceleration of the Diels-Alder Reaction by Microwave Irradiation for the Synthesis of New Fluorine-Substituted Ligands of NMDA Receptor,Bioorg.Med.Chem. Lett.,8, 2983-2986 (1998).
  152. Haradahira T. Sasaki S. Maeda M. Kobayashi K. Inoue O. Tomita U. Nishikawa T. Suzuki K.; Synthesis and BrainDistribution of Carbon-11 Labeled Analogs of Antagonists for the NMDA Receeptor Coupled PCP-Binding Site.J. Labelled.Cpd. Radiopharm.,41, 843-858 (1998).

  153. Nagatsugi F., Uemura K., Nakashima S., Maeda M., Sasaki S., 2-Aminopurine Derivatives with C6-Substituted Olefin asNovel Cross-Linking Agents and the Synthesis of the Corresponding b-Phosphoramidite Precursors,Tetrahedron,53, 3035-3044 (1997).
  154. Nakashima S., Matsuura N., Nagatsugi F., Maeda M., Sasaki S., Synthesis and Evaluation of OligonucleotidesIncorporating Novel Artificial Nucleobases for the Selective Formation of Non-Natural Type Triplexes,Nucleic Acids, Symp.Ser.,37, 33-34 (1997).
  155. Nagatsugi F., Kawasaki T., Maeda M., Sasaki S., Novel Cross-Linking Reaction of Oligonuceotides Incorporating New BaseAnalogs with Selective Reactivity towad Cytidine,Nucleic Acids, Symp. Ser.,37, 67-68 (1997).
  156. Nagatsugi F., Uemura K., Nakashima S., Maeda M., Sasaki S., 2-Aminopurine Derivatives with C6-Substituted Olefin asNovel Cross-Linking Agents and the Synthesis of the Corresponding b-Phosphoramidite Precursors,Tetrahedron,53, 3035-3044 (1997).
  157. Nakashima S., Matsuura N., Nagatsugi F., Maeda M., Sasaki S., Synthesis and Evaluation of OligonucleotidesIncorporating Novel Artificial Nucleobases for the Selective Formation of Non-Natural Type Triplexes,Nucleic Acids, Symp.Ser.,37, 33-34 (1997).
  158. Nagatsugi F., Kawasaki T., Maeda M., Sasaki S., Novel Cross-Linking Reaction of Oligonuceotides Incorporating New BaseAnalogs with Selective Reactivity towad Cytidine,Nucleic Acids, Symp. Ser.,37, 67-68 (1997).

  1. Shigeki Sasaki, Yosuke Taniguchi, Fumi Nagatsugi, 「SpecificRecognition of Single Nucleotide by AlkylatingOligonucleotides and Sensing of8-Oxoguanine」、Springer, 31, 221-248 (2016)  
  2. 中川治、佐々木茂貴 「核酸をトリガーとする増幅反応」、化学、化学同人、60、70-71(2005)
  3. 谷口陽祐、佐々木茂貴 「3本鎖DNA認識コード拡張のための人工ヌクレオシドの開発」、有機合成化学協会誌、62、1026-1037(2004)
  4. 佐々木茂貴 「ゲノムケミストリー」(関根光雄、齋藤烈 編)、第2章ゲノムに機能する人工核酸、2.6ゲノムクロスリンク能をもつ人工核酸、講談社、東京、89-100(2003)
  5. 佐々木茂貴 「インテリジェント材料・技術の最新開発動向、インテリジェント機能性核酸の創製」、シーエムシー出版(2003)
  6. 佐々木茂貴、永次史 「遺伝子発現機構を標的とする核酸医薬品の新しい化学」、ファルマシア(2003)
  7. 佐々木茂貴 「ゲノム標的化学遺伝子に働くロボットを目指して」、日本化学会生体機能関連化学部会ニュースレター、17、101-104(2003)
  8. 佐々木茂貴 「放射薬品化学」、第5章標識化合物の合成、廣川書店、東京(1999)
  9. 佐々木茂貴 「3本鎖DNA形成による遺伝子発現の化学的制御(アンチジーン法)のための分子設計」、有機合成化学協会誌、55、590-599(1997)
  10. 佐々木茂貴 「コンビナトリアルケミストリー」、蛋白質表面認識分子探索のためのコンビナトリアルテクノロジーの応用−水溶液中での小さなペプチド同士の強い相互作用の検索−、化学同人、京都、99-101(1997)